ArticleTurkish journal of anaesthesiology and reanimation2017
Association of Low Blood Pressure, Low Bispectral Index and Low Minimum Alveolar Concentration of Anaesthetic during Surgery with Postoperative 30-day Mortality: A Systemic Review and Meta-Analysis.
Article in Turkish journal of anaesthesiology and reanimation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe triple low state [low mean arterial pressure, low bispectral index (BIS) and a low minimum alveolar concentration (MAC)] fraction of anaesthetic during surgery) has been a controversial subject of interest in clinical practise. Previous retrospective studies have produced different conclusions on the association between a triple low state and postoperative 30-day mortality. This study was a systematic review of previous studies on the effects of the triple low state on postoperative 30-day mortality and a meta-analysis with a sample size larger than that of previous studies.
methodsAfter searching for relevant articles in the PubMed database as on 27 March 2017, we included studies that compared postoperative 30-day mortality between triple low and non-triple low groups. The identified articles were subjected to an initial screening using keywords 'low bispectral index', 'intraoperative hypotension' and 'low minimum alveolar concentration' according to the PRISMA Flow diagram (2009). After a full-text review, appropriate studies were finally included in our meta-analysis. All statistical analyses were performed using the R programme 3.3.2 and meta packages.
resultsThree retrospective cohort studies were included in the meta-analysis. The total number of subjects in the triple low and non-triple low groups was 29,402 and 17,428, respectively; the sample size was 46,830. We derived a hazard ratio (HR) of 1.09 [95% confidence interval (CI), 1.07-1.11)] for the fixed effect model and of 1.30 (95% CI, 1.04-1.07) for the random effect model. In the analysis of heterogeneity among the three studies, I2=95% was obtained (P<0.01). Thus, the values obtained from the random effect model were used; HR was 1.30 for the triple low group, indicating a 30% increase in the overall 30-day mortality.
conclusionThe present study demonstrated that patients exposed to the triple low state exhibit higher 30-day mortality rates than those not exposed to the triple low state.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.