Evidence map›Paper›PMID 29358940›Full record

ArticleFrontiers in immunology2017

Directed Differentiation of Human Induced Pluripotent Stem Cells into Dendritic Cells Displaying Tolerogenic Properties and Resembling the CD141

Patty Sachamitr, Alison J Leishman, Timothy J Davies, Paul J Fairchild

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. The Application of iPSCs in Tumour Immunotherapy.Expert reviews in molecular medicine · 2025
    Review
  3. Article
  4. Review
  5. Review
  6. Theranostics · 2025
    Article
  7. The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Review
  9. Guidelines for Manufacturing and Application of Organoids: Skin.International journal of stem cells · 2024
    Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Human pluripotent stem cells for the modelling and treatment of respiratory diseases.European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Patty SachamitrSir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
Alison J LeishmanSir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
Timothy J DaviesSir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
Paul J FairchildSir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
University of Oxford · GB

Funding

Medical Research Council G0802538Medical Research Council MC_PC_15029Medical Research Council MC_PC_16056
6 · The paper itself

Abstract

The advent of induced pluripotent stem cells (iPSCs) has begun to revolutionize cell therapy by providing a convenient source of rare cell types not normally available from patients in sufficient numbers for therapeutic purposes. In particular, the development of protocols for the differentiation of populations of leukocytes as diverse as naïve T cells, macrophages, and natural killer cells provides opportunities for their scale-up and quality control prior to administration. One population of leukocytes whose therapeutic potential has yet to be explored is the subset of conventional dendritic cells (DCs) defined by their surface expression of CD141. While these cells stimulate cytotoxic T cells in response to inflammation through the cross-presentation of viral and tumor-associated antigens in an MHC class I-restricted manner, under steady-state conditions CD141

Indexed as

CD141dendritic celldirected differentiationinduced pluripotent stem cellregulatory T celltolerance

Identifiers

PMID29358940
PMCPMC5766641
OpenAlexW2782507410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.