Association of Peripheral Interleukin-6 with Global Cognitive Decline in Non-demented Adults: A Meta-Analysis of Prospective Studies.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.

1. Predictors of cognitive decline in older individuals without dementia: An updated meta-analysis.Annals of clinical and translational neurology · 2023
   Pooled it
2. Effects of Semaglutide on Cognitive Function in People With HIV: A Randomized, Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
   Trial
3. Geriatric Oncology multidomain intervention study to prevent Cognitive impairment among older Indian patients with cancer receiving chemotherapy: a multicentric randomised controlled trial (GOCog).BMC geriatrics · 2026
   Trial
4. Mindfulness improves inflammatory biomarker levels in older adults with mild cognitive impairment: a randomized controlled trial.Translational psychiatry · 2020
   Trial
5. An exploratory randomized sub-study of light-to-moderate intensity exercise on cognitive function, depression symptoms and inflammation in older adults with heart failure.Journal of psychosomatic research · 2020
   Trial
6. [Mechanisms of cGAS-STING-mediated chronic inflammation and targeted interventions in brain aging].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026
   Review
7. The Role of Dopamine Signaling and Neuroinflammation in Age-Related Cognitive Dysfunction.Brain and behavior · 2026
   Article
8. Sexual minority adults exhibit greater inflammation than heterosexual adults in the context of depressive symptoms and anxiety: Pathways to health disparities.Brain, behavior, and immunity · 2026
   Article
9. Cardiometabolic risk mediates the association between perceived stress and learning and memory similarly among Hispanic/Latino and non-Hispanic White individuals.Journal of clinical and experimental neuropsychology · 2026
   Observational
10. Mechanistic insights into the liver-brain axis during chronic liver disease.Nature reviews. Gastroenterology & hepatology · 2026
    Review
11. Associations between white matter lesions, adiposity, and systemic inflammation in late adulthood: Results from the IGNITE study.Brain, behavior, and immunity · 2026
    Article
12. Chronic high-altitude exposure is associated with an internally-directed perceptual shift: differential links with attention networks and autonomic regulation.Frontiers in neuroscience · 2026
    Article
13. Interleukin-6, CD8Frontiers in aging neuroscience · 2026
    Review
14. The relation between postoperative cognitive disorders and brain damage biomarkers after major urologic surgery: a prospective cohort study.Perioperative medicine (London, England) · 2025
    Article
15. Higher interleukin-6 (IL-6) is associated with decline in psychomotor processing speed but not executive functioning in older adults: Gender-specific effects.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
16. Inflammation and Cognition in Bipolar Disorder: Diverging Paths of Interleukin-6 and Outcomes.International journal of molecular sciences · 2025
    Article
17. Effects of Mind-Body Interventions on Immune and Neuroendocrine Functions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Healthcare (Basel, Switzerland) · 2025
    Review
18. Therapeutics Potential of Cronassial in Experimental Autoimmune Encephalomyelitis: Insights Into Glycosphingolipids and Humoral Immunity.TheScientificWorldJournal · 2025
    Article
19. Biofluid biomarkers for Alzheimer's disease: past, present, and future.Medical review (2021) · 2024
    Review
20. Inflammation and cognitive performance in elite athletes: A cross-sectional study.Brain, behavior, & immunity - health · 2024
    Article

12 more citing papers are in PubMed but not listed here.

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

3 authors at 2 institutions in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as