ReviewFrontiers in neuroanatomy2017
Trigeminal, Visceral and Vestibular Inputs May Improve Cognitive Functions by Acting through the Locus Coeruleus and the Ascending Reticular Activating System: A New Hypothesis.
Review in Frontiers in neuroanatomy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Clinical and cognitive effects of external trigeminal nerve stimulation (eTNS) in neurological and psychiatric disorders: a systematic review and meta-analysis.Molecular psychiatry · 2023Pooled it
- Effects and neuroprotective mechanisms of vagus nerve stimulation on cognitive impairment with traumatic brain injury in animal studies: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- Human translingual neurostimulation alters resting brain activity in high-density EEG.Journal of neuroengineering and rehabilitation · 2019Trial
- Associations Between the Vestibulo-Ocular Reflex and Cognitive Function in de novo Parkinson's Disease.Journal of movement disorders · 2026Article
- Hippocampal rhythm modulation via frequency-tuned trigeminal nerve stimulation.Translational psychiatry · 2026Article
- The effects of online movement therapy on physical activity and sleep in persistent postural-perceptual dizziness.Journal of neurology · 2026Article
- Neurotransmitter regulatory networks in persistent postural-perceptual dizziness: potential mechanisms and therapeutic implications.Frontiers in neurology · 2026Review
- Chewing modulates theta oscillation and functional connectivity of the frontocentral cortex in attention and working memory.Scientific reports · 2025Article
- Trigeminal Nerve and Vestibular System: Update on Pathophysiological and Clinical Links.Audiology research · 2025Review
- Transcranial Direct Current Stimulation in Older Adolescent with Chronic Mild Traumatic Brain Injury: A Case Study of Clinical and Functional Connectivity.Research square · 2025Article
- Review
- Effects of Clenching Strength on Step Reaction Time.Journal of functional morphology and kinesiology · 2025Article
- Murine nasal-associated lymphoid tissue (NALT) harbors human alphaherpesvirus 1 (HSV-1) DNA during latency, and dexamethasone triggers viral replication.Journal of virology · 2025Article
- Rescue-like behavior in a bystander mouse toward anesthetized conspecifics promotes arousal via a tongue-brain connection.Science advances · 2025Article
- Differences in Coma Recovery Scale-Revised performance in an upright position versus lying position.Frontiers in neurology · 2025Article
- Effects of chewing on postural learning: An experimental pre-post intervention study.PloS one · 2025Article
- Understanding novel neuromodulation pathways in tDCS: brain stem recordings in rats during trigeminal nerve direct current stimulation.Translational psychiatry · 2024Article
- The influence of transcranial direct current stimulation to the trigeminal nerve on attention and arousal.Cognitive, affective & behavioral neuroscience · 2024Article
- Article
- Clinical Potential of Transcranial Focused Ultrasound for Neurorehabilitation in Pediatric Cancer Survivors.Brain sciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is known that sensory signals sustain the background discharge of the ascending reticular activating system (ARAS) which includes the noradrenergic locus coeruleus (LC) neurons and controls the level of attention and alertness. Moreover, LC neurons influence brain metabolic activity, gene expression and brain inflammatory processes. As a consequence of the sensory control of ARAS/LC, stimulation of a sensory channel may potential influence neuronal activity and trophic state all over the brain, supporting cognitive functions and exerting a neuroprotective action. On the other hand, an imbalance of the same input on the two sides may lead to an asymmetric hemispheric excitability, leading to an impairment in cognitive functions. Among the inputs that may drive LC neurons and ARAS, those arising from the trigeminal region, from visceral organs and, possibly, from the vestibular system seem to be particularly relevant in regulating their activity. The trigeminal, visceral and vestibular control of ARAS/LC activity may explain why these input signals: (1) affect sensorimotor and cognitive functions which are not directly related to their specific informational content; and (2) are effective in relieving the symptoms of some brain pathologies, thus prompting peripheral activation of these input systems as a complementary approach for the treatment of cognitive impairments and neurodegenerative disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.