Evidence map›Paper›PMID 29358877›Full record

ReviewWorld journal of gastroenterology2018

Relationship between intestinal microbiota and ulcerative colitis: Mechanisms and clinical application of probiotics and fecal microbiota transplantation.

Zhao-Hua Shen, Chang-Xin Zhu, Yong-Sheng Quan, Zhen-Yu Yang, Shuai Wu, Wei-Wei Luo, Bei Tan, Xiao-Yan Wang

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05035784 (Retrograde Colonic Enema With Fecal Microbiota Transplantation vs Retrograde Colonic Enema Only in the Treatment of Childhood Constipation), which is not on this map. Cited by 350 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
350citing papers in PubMed, 7 pooled it
16.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05035784 nacompletednot on this mapstarted 2020, after this paper: background citation

Retrograde Colonic Enema With Fecal Microbiota Transplantation vs Retrograde Colonic Enema Only in the Treatment of Childhood Constipation

TypeinterventionalSponsorShengjing HospitalRan2020 to 2022Enrolled110ConditionsFecal Microbiota Transplantation, Constipation - FunctionalArmsFecal supernatant, Placebo
3 · Its place in the literature

Who cites it

350 citing papers in PubMed, 7 syntheses or guidelines pooled it, 637 citations in OpenAlex.

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290 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zhao-Hua ShenDepartment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Chang-Xin ZhuDepartment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Yong-Sheng QuanDepartment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Zhen-Yu YangDepartment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Shuai WuDepartment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Wei-Wei LuoDepartment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Bei TanDepartment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Xiao-Yan WangDepartment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Central South University · CNThird Xiangya Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ulcerative colitis (UC) is an inflammatory disease that mainly affects the colon and rectum. It is believed that genetic factors, host immune system disorders, intestinal microbiota dysbiosis, and environmental factors contribute to the pathogenesis of UC. However, studies on the role of intestinal microbiota in the pathogenesis of UC have been inconclusive. Studies have shown that probiotics improve intestinal mucosa barrier function and immune system function and promote secretion of anti-inflammatory factors, thereby inhibiting the growth of harmful bacteria in the intestine. Fecal microbiota transplantation (FMT) can reduce bowel permeability and thus the severity of disease by increasing the production of short-chain fatty acids, especially butyrate, which help maintain the integrity of the epithelial barrier. FMT can also restore immune dysbiosis by inhibiting Th1 differentiation, activity of T cells, leukocyte adhesion, and production of inflammatory factors. Probiotics and FMT are being increasingly used to treat UC, but their use is controversial because of uncertain efficacy. Here, we briefly review the role of intestinal microbiota in the pathogenesis and treatment of UC.

Indexed as

Fecal Microbiota TransplantationGastrointestinal MicrobiomeAnimalsBacteriaColitis, UlcerativeColonHost-Pathogen InteractionsHumansProbioticsTreatment OutcomeClinical applicationFecal microbiota transplantationIntestinal microbiotaMechanismProbioticsUlcerative colitis

Identifiers

PMID29358877
PMCPMC5757125
OpenAlexW2782401411

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.