Evidence map›Paper›PMID 29358858›Full record

ArticleWorld journal of gastroenterology2017

Influence of TBX21 T-1993C variant on autoimmune hepatitis development by Yin-Yang 1 binding.

Wei Sun, Hong-Yan Wu, Song Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Pathogenesis of autoimmune hepatitis.World journal of hepatology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Wei SunInstitute of Infectious Diseases, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China.
Hong-Yan WuNuclear Medicine Department, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
Song ChenInstitute of Infectious Diseases, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China cs196@medmail.com.cn.
Chongqing Medical University · CNSouthwest General Health Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigated the mechanism of the association between the TBX21 T-1993C promoter polymorphism and autoimmune hepatitis type 1 (AIH-1) development.

methods

resultsTBX21-1993C allele created a strong Yin-Yang 1 (YY1)-binding site and decreased transcriptional activity of TBX21 promoter in human CD4

conclusionThe repression of TBX21 expression by high-affinity binding of YY1 to the -1993C allele may contribute to a decreased development of AIH-1

Indexed as

Genetic Predisposition to DiseaseAdultAllelesFemaleFlow CytometryGene Knockdown TechniquesGenotypeHepatitis, AutoimmuneHumansInterferon-gammaLeukocytes, MononuclearLymphocyte ActivationMaleMiddle AgedPolymorphism, Single NucleotidePromoter Regions, GeneticInterferon-gammaRNA, Small InterferingT-bet Transcription FactorT-Box Domain ProteinsYY1 protein, humanYY1 Transcription FactorAutoimmune hepatitisB cellsSingle nucleotide polymorphismTBX21T helper cellsYin-Yang 1

Identifiers

PMID29358858
PMCPMC5752710
OpenAlexW2777928160

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.