ArticleScientific reports2018
Impaired Functional Criticality of Human Brain during Alzheimer's Disease Progression.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 40 citations in OpenAlex.
- Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Criticality and increased intrinsic neural timescales in stroke.NPJ systems biology and applications · 2025Article
- sPGGM: a sample-perturbed Gaussian graphical model for identifying pre-disease stages and signaling molecules of disease progression.National science review · 2025Article
- The Role of circRNAs in the Pathological Mechanisms of Alzheimer's Disease: Potential Biomarkers for Diagnosis.Current neuropharmacology · 2025Review
- A graph neural network approach to investigate brain critical states over neurodevelopment.Network neuroscience (Cambridge, Mass.) · 2025Article
- Role of homeostatic plasticity in critical brain dynamics following focal stroke lesions.Scientific reports · 2024Article
- Detecting tipping points of complex diseases by network information entropy.Briefings in bioinformatics · 2024Article
- Caffeine, Postoperative Delirium And Change In Outcomes after Surgery (CAPACHINOS)-2: protocol for a randomised controlled trial.BMJ open · 2023Article
- Structural Modularity Tunes Mesoscale Criticality in Biological Neuronal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Artificial neural network applied to fragile X-associated tremor/ataxia syndrome stage diagnosis based on peripheral mitochondrial bioenergetics and brain imaging outcomes.Scientific reports · 2022Article
- Recovery of neural dynamics criticality in personalized whole-brain models of stroke.Nature communications · 2022Article
- Cortical Volume in the Right Cingulate Cortex Mediates the Increase of Self-Control From Young Adult to Middle-Aged.Frontiers in behavioral neuroscience · 2022Article
- Quasicriticality explains variability of human neural dynamics across life span.Frontiers in computational neuroscience · 2022Article
- Screening of Human Circular RNAs as Biomarkers for Early Onset Detection of Alzheimer's Disease.Frontiers in neuroscience · 2022Article
- Decreased Resting-State Functional Complexity in Elderly with Subjective Cognitive Decline.Entropy (Basel, Switzerland) · 2021Article
- Article
- Longitudinal change in hippocampal and dorsal anterior insulae functional connectivity in subjective cognitive decline.Alzheimer's research & therapy · 2021Article
- Distance-based functional criticality in the human brain: intelligence and emotional intelligence.BMC bioinformatics · 2021Article
- Fusion analysis of gray matter and white matter in subjective cognitive decline and mild cognitive impairment by multimodal CCA-joint ICA.NeuroImage. Clinical · 2021Article
- Criticality, Connectivity, and Neural Disorder: A Multifaceted Approach to Neural Computation.Frontiers in computational neuroscience · 2021Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The progression of Alzheimer's Disease (AD) has been proposed to comprise three stages, subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD. Was brain dynamics across the three stages smooth? Was there a critical transition? How could we characterize and study functional criticality of human brain? Based on dynamical characteristics of critical transition from nonlinear dynamics, we proposed a vertex-wise Index of Functional Criticality (vIFC) of fMRI time series in this study. Using 42 SCD, 67 amnestic MCI (aMCI), 34 AD patients as well as their age-, sex-, years of education-matched 54 NC, our new method vIFC successfully detected significant patient-normal differences for SCD and aMCI, as well as significant negative correlates of vIFC in the right middle temporal gyrus with total scores of Montreal Cognitive Assessment (MoCA) in SCD. In comparison, standard deviation of fMRI time series only detected significant differences between AD patients and normal controls. As an index of functional criticality of human brain derived from nonlinear dynamics, vIFC could serve as a sensitive neuroimaging marker for future studies; considering much more vIFC impairments in aMCI compared to SCD and AD, our study indicated aMCI as a critical stage across AD progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.