ArticleHeredity2018
Fine-scale landscape genomics helps explain the slow spatial spread of Wolbachia through the Aedes aegypti population in Cairns, Australia.
Article in Heredity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 113 citations in OpenAlex.
- Interactions Between Inbreeding, Fitness and the Bacterial Microbiome inEvolutionary applications · 2026Article
- Interactions between mosquito genetic background and Wolbachia strain affect dengue virus blocking and fitness in South American populations of Aedes aegypti.PLoS neglected tropical diseases · 2026Article
- A targeted amplicon sequencing panel for cost-effective high-throughput genotyping of Aedes aegypti.Parasites & vectors · 2026Article
- Spatial close-kin mark-recapture methods to estimate dispersal parameters and barrier strength for mosquitoes.PLoS computational biology · 2025Article
- Midgut microbiota diversity and interactions shift when field Aedes aegypti mosquitoes carry the wMel strain of Wolbachia pipientis.Communications biology · 2025Article
- Natural salivary gland barrier curtails Zika virus transmission in Thai Aedes aegypti.PLoS neglected tropical diseases · 2025Article
- A targeted amplicon sequencing panel for cost-effective high-throughput genotyping ofbioRxiv : the preprint server for biology · 2025Article
- Gene Flow and Abundance of a Tropical Fruit Fly in a Horticultural Landscape Mosaic in Eastern Australia Is Limited by Cleared Grazing Land and Area-Wide Management.Evolutionary applications · 2025Article
- ExploitingPathogens (Basel, Switzerland) · 2025Review
- The genetic trail of the invasive mosquito species Aedes koreicus from the east to the west of Northern Italy.PLoS neglected tropical diseases · 2025Article
- Article
- Review
- Assessing the direct and spillover protective effectiveness of Wolbachia-mediated introgression to combat dengue.EBioMedicine · 2024Article
- MGSurvE: A framework to optimize trap placement for genetic surveillance of mosquito populations.PLoS computational biology · 2024Article
- Microsatellite-based analysis revealsEvolutionary applications · 2024Article
- Efficacy of Wolbachia-based mosquito control: Predictions of a spatially discrete mathematical model.PloS one · 2024Article
- Aedes aegypti microbiome composition covaries with the density of Wolbachia infection.Microbiome · 2023Article
- Leveraging insect-specific viruses to elucidate mosquito population structure and dynamics.PLoS pathogens · 2023Review
- Biology and Behaviour ofViruses · 2023Review
- Using models and maps to inform Target Product Profiles and Preferred Product Characteristics: the example ofGates open research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endosymbiotic bacterium Wolbachia suppresses the capacity for arbovirus transmission in the mosquito Aedes aegypti, and can spread spatially through wild mosquito populations following local introductions. Recent introductions in Cairns, Australia have demonstrated slower than expected spatial spread. Potential reasons for this include: (i) barriers to Ae. aegypti dispersal; (ii) higher incidence of long-range dispersal; and (iii) intergenerational loss of Wolbachia. We investigated these three potential factors using genome-wide single-nucleotide polymorphisms (SNPs) and an assay for the Wolbachia infection wMel in 161 Ae. aegypti collected from Cairns in 2015. We detected a small but significant barrier effect of Cairns highways on Ae. aegypti dispersal using distance-based redundancy analysis and patch-based simulation analysis. We detected a pair of putative full-siblings in ovitraps 1312 m apart, indicating long-distance female movement likely mediated by human transport. We also found a pair of full-siblings of different infection status, indicating intergenerational loss of Wolbachia in the field. These three factors are all expected to contribute to the slow spread of Wolbachia through Ae. aegypti populations, though from our results it is unclear whether Wolbachia loss and long-distance movement are sufficiently common to reduce the speed of spatial spread appreciably. Our findings inform the strategic deployment of Wolbachia-infected mosquitoes during releases, and show how parameter estimates from laboratory studies may differ from those estimated using field data. Our landscape genomics approach can be extended to other host/symbiont systems that are being considered for biocontrol.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.