ArticleScientific reports2018
Investigation of Candida parapsilosis virulence regulatory factors during host-pathogen interaction.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Dissection of innate-immune-ligand- and interferon-protein-mediated transcriptional responses in human THP1 cell states.Communications biology · 2026Article
- Persistence and spread of fluconazole-resistantMicrobial genomics · 2026Article
- Fungal coexistence in the skin mycobiome: a study involving Malassezia, Candida, and Rhodotorula.AMB Express · 2024Article
- Clinical, Epidemiological and Laboratory Features of InvasiveJournal of fungi (Basel, Switzerland) · 2023Article
- Culture media influencesFrontiers in cellular and infection microbiology · 2023Article
- Article
- Enhancing the chemical transformation ofVirulence · 2021Article
- The transcription factor Ndt80 is a repressor of Candida parapsilosis virulence attributes.Virulence · 2021Article
- Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells.Nature microbiology · 2021Article
- Article
- AJournal of fungi (Basel, Switzerland) · 2021Article
- Article
- A Re-Evaluation of the Relationship between Morphology and Pathogenicity inJournal of fungi (Basel, Switzerland) · 2020Review
- Identification and Characterization of a Neutral Locus for Knock-in Purposes inFrontiers in microbiology · 2020Article
- Article
- Article
- Candida parapsilosis: from Genes to the Bedside.Clinical microbiology reviews · 2019Review
- Identification of an Exceptionally Long Intron in themSphere · 2018Article
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Authors and funding
12 authors.
Funding
Abstract
Invasive candidiasis is among the most life-threatening infections in patients in intensive care units. Although Candida albicans is the leading cause of candidaemia, the incidence of Candida parapsilosis infections is also rising, particularly among the neonates. Due to differences in their biology, these species employ different antifungal resistance and virulence mechanisms and also induce dissimilar immune responses. Previously, it has been suggested that core virulence effecting transcription regulators could be attractive ligands for future antifungal drugs. Although the virulence regulatory mechanisms of C. albicans are well studied, less is known about similar mechanisms in C. parapsilosis. In order to search for potential targets for future antifungal drugs against this species, we analyzed the fungal transcriptome during host-pathogen interaction using an in vitro infection model. Selected genes with high expression levels were further examined through their respective null mutant strains, under conditions that mimic the host environment or influence pathogenicity. As a result, we identified several mutants with relevant pathogenicity affecting phenotypes. During the study we highlight three potentially tractable signaling regulators that influence C. parapsilosis pathogenicity in distinct mechanisms. During infection, CPAR2_100540 is responsible for nutrient acquisition, CPAR2_200390 for cell wall assembly and morphology switching and CPAR2_303700 for fungal viability.
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