Evidence map›Paper›PMID 29358697›Full record

ArticleScientific reports2018

Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates skeletal muscle via macrophage and satellite cell activation.

Takuya Oyaizu, Mitsuhiro Enomoto, Naoki Yamamoto, Kunikazu Tsuji, Masaki Horie, Takeshi Muneta, Ichiro Sekiya, Atsushi Okawa, Kazuyoshi Yagishita

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 83 citations in OpenAlex.

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  13. Aligned Collagen Sponges Loaded With Myogenic Factors to Enhance Skeletal Muscle Tissue Regeneration.Journal of biomedical materials research. Part B, Applied biomaterials · 2025
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  15. Effect ofDentistry journal · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Takuya OyaizuDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8519, Japan.
Mitsuhiro EnomotoHyperbaric Medical Center, Medical Hospital, Tokyo Medical and Dental University, Tokyo, 113-8519, Japan. enomorth@tmd.ac.jp.
Naoki YamamotoDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8519, Japan.
Kunikazu TsujiDepartment of Cartilage Regeneration, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8519, Japan.
Masaki HorieHyperbaric Medical Center, Medical Hospital, Tokyo Medical and Dental University, Tokyo, 113-8519, Japan.
Takeshi MunetaDepartment of Joint Surgery and Sports Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8519, Japan.
Ichiro SekiyaCenter for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8519, Japan.ORCID http://orcid.org/0000-0002-6331-722X
Atsushi OkawaDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8519, Japan.
Kazuyoshi YagishitaHyperbaric Medical Center, Medical Hospital, Tokyo Medical and Dental University, Tokyo, 113-8519, Japan.
Tokyo Medical and Dental University · JPTokyo Medical and Dental University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperbaric oxygen treatment (HBO) promotes rapid recovery from soft tissue injuries. However, the healing mechanism is unclear. Here we assessed the effects of HBO on contused calf muscles in a rat skeletal muscle injury model. An experimental HBO chamber was developed and rats were treated with 100% oxygen, 2.5 atmospheres absolute for 2 h/day after injury. HBO reduced early lower limb volume and muscle wet weight in contused muscles, and promoted muscle isometric strength 7 days after injury. HBO suppressed the elevation of circulating macrophages in the acute phase and then accelerated macrophage invasion into the contused muscle. This environment also increased the number of proliferating and differentiating satellite cells and the amount of regenerated muscle fibers. In the early phase after injury, HBO stimulated the IL-6/STAT3 pathway in contused muscles. Our results demonstrate that HBO has a dual role in decreasing inflammation and accelerating myogenesis in muscle contusion injuries.

Indexed as

AnimalsCell DifferentiationCell ProliferationGene Expression RegulationHyperbaric OxygenationInflammationInterleukin-6Isometric ContractionMacrophagesMaleMuscle DevelopmentMuscle, SkeletalOxygenRatsRats, WistarRecovery of FunctionIl6 protein, ratInterleukin-6OxygenStat3 protein, ratSTAT3 Transcription Factor

Identifiers

PMID29358697
PMCPMC5778072
OpenAlexW2782598352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.