ArticleNature communications2018
An integrated multi-layer 3D-fabrication of PDA/RGD coated graphene loaded PCL nanoscaffold for peripheral nerve restoration.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.
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Who cites it
122 citing papers in PubMed, 344 citations in OpenAlex.
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- Smart-responsive electrospun scaffolds (SRES) for neural repair: Recent advances and future prospects.Bioactive materials · 2026Review
- Multiscale biomimetic design for peripheral nerve repair: Beyond passive bridging.Materials today. Bio · 2026Review
- Hierarchical microtopology and phase-specific delivery functionally restore ultralong nerve continuity across species.Science advances · 2026Article
- Recent Advances and Applications of Chitin and Chitosan Hydrogel Scaffolds in Tissue Engineering.Gels (Basel, Switzerland) · 2026Review
- Toward 4D printed functional soft tissues.Acta biomaterialia · 2026Review
- Advanced Flexible Bioelectrodes for Next-Generation Implantable Triboelectric Nanogenerators.International journal of biomaterials · 2026Article
- Electroactive biomaterials modulating ion channels in nervous system regeneration.Regenerative biomaterials · 2026Review
- Article
- Advances in 3D bioprinting for medical application: opportunities and challenges.Biomedical engineering online · 2025Review
- Conductive Nerve Conduits With Orientated Topological Structures From Ice-Templating Technology.Smart medicine · 2025Article
- Controlling T cell-tumor cell interaction with a biomimetic physical barrier for cancer immunotherapy.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Synergistic effects of electrical and chemical cues with biodegradable scaffolds for large peripheral nerve defect regeneration.Bioactive materials · 2025Article
- Advanced development of conductive biomaterials for enhanced peripheral nerve regeneration: a review.RSC advances · 2025Review
- An immunoregulation PLGA/Chitosan aligned nanofibers with polydopamine coupling basic fibroblast growth factor and ROS scavenging for peripheral nerve regeneration.Materials today. Bio · 2025Article
- 3D printed biodegradable hydrogel-based multichannel nerve conduits mimicking peripheral nerve fascicules.Materials today. Bio · 2025Article
- A Comprehensive Review on Bioprinted Graphene-Based Material (GBM)-Enhanced Scaffolds for Nerve Guidance Conduits.Biomimetics (Basel, Switzerland) · 2025Review
- Advanced Hydrogels: Enhancing Tissue Bioengineering with RGD Peptides and Carbon Nanomaterials.ChemMedChem · 2025Review
62 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a conductive nanomaterial, graphene has huge potentials in nerve function restoration by promoting electrical signal transduction and metabolic activities with unique topological properties. Polydopamine (PDA) and arginylglycylaspartic acid (RGD) can improve cell adhesion in tissue engineering. Here we report an integrated 3D printing and layer-by-layer casting (LBLC) method in multi-layered porous scaffold fabrication. The scaffold is composed of single-layered graphene (SG) or multi-layered graphene (MG) and polycaprolactone (PCL). The electrically conductive 3D graphene scaffold can significantly improve neural expression both in vitro and in vivo. It promotes successful axonal regrowth and remyelination after peripheral nerve injury. These findings implicate that graphene-based nanotechnology have great potentials in peripheral nerve restoration in preclinical and clinical application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.