Evidence map›Paper›PMID 29358433›Full record

Trial reportBMJ open2018

Randomised controlled trial to determine the efficacy and safety of prescribed water intake to prevent kidney failure due to autosomal dominant polycystic kidney disease (PREVENT-ADPKD).

Annette T Y Wong, Carly Mannix, Jared J Grantham, Margaret Allman-Farinelli, Sunil V Badve, Neil Boudville, Karen Byth, Jessie Chan, Susan Coulshed, Marie E Edwards and 24 more

Erratum issuedOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 4 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 86 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

34 authors at 13 institutions in 2 countries.

Annette T Y WongCentre for Transplant and Renal Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.
Carly MannixCentre for Transplant and Renal Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.
Jared J GranthamThe Kidney Institute, Division of Nephrology and Hypertension, Kansas University Medical Center, Kansas City, Kansas, USA.
Margaret Allman-FarinelliSchool of Life and Environmental Sciences, The Charles Perkins Centre, The University of Sydney, Sydney, Australia.
Sunil V BadveDepartment of Renal Medicine, St. George Hospital, Sydney, Australia.
Neil BoudvilleDepartment of Renal Medicine, Sir Charles Gairdner Hospital, Nedlands and the Harry Perkins Institute of Medical Research, University of Western Australia, Sydney, Australia.
Karen BythResearch and Education Network, Westmead Hospital, Western Sydney Local Health District, Sydney, Australia.
Jessie ChanMcCloud Consulting Group, Gordon, Australia.
Susan CoulshedNorth Shore Nephrology, Crows Nest, Australia.
Marie E EdwardsTranslational Polycystic Kidney Disease Center, Mayo Clinic, Rochester, Minnesota, USA.
Bradley J EricksonTranslational Polycystic Kidney Disease Center, Mayo Clinic, Rochester, Minnesota, USA.
Mangalee FernandoDepartment of Renal Medicine, Prince of Wales Hospital, Eastern Sydney Health District and the University of New South Wales, Randwick, Australia.
Sheryl FosterDepartment of Radiology, Westmead Hospital, Western Sydney Local Health District, Sydney, Australia.
Imad HaloobDepartment of Renal Medicine, Bathurst Base Hospital, Bathurst, Australia.
David C H HarrisCentre for Transplant and Renal Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.
Carmel M HawleyAustralasian Kidney Trials Network, University of Queensland at Princess Alexandra Hospital, Woolloongabba, Australia.
Julie HillMcCloud Consulting Group, Gordon, Australia.
Kirsten HowardSchool of Public Health, University of Sydney, Sydney, Australia.
Martin HowellSchool of Public Health, University of Sydney, Sydney, Australia.
Simon H JiangDepartment of Renal Medicine, Canberra Hospital, Garran, Australia.
David W JohnsonAustralasian Kidney Trials Network, University of Queensland at Princess Alexandra Hospital, Woolloongabba, Australia.
Timothy L KlineTranslational Polycystic Kidney Disease Center, Mayo Clinic, Rochester, Minnesota, USA.
Karthik KumarGosford Nephrology, Gosford, Australia.
Vincent W LeeCentre for Transplant and Renal Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.
Maureen LonerganDepartment of Renal Medicine, Wollongong Hospital, Illawarra Shoalhaven Local Health District, Wollongong, Australia.
Jun MaiDepartment of Renal Medicine, Liverpool Hospital, Southwestern Sydney Local Health District, Liverpool, Australia.
Philip McCloudMcCloud Consulting Group, Gordon, Australia.
Anthony PedutoDepartment of Radiology, Westmead Hospital, Western Sydney Local Health District, Sydney, Australia.
Anna RanganSchool of Life and Environmental Sciences, The Charles Perkins Centre, The University of Sydney, Sydney, Australia.
Simon D RogerRenal Research, Gosford, Australia.
Kamal SudDepartment of Renal Medicine, Westmead Hospital, Western Sydney Local Health District, Sydney, Australia.
Vincent TorresTranslational Polycystic Kidney Disease Center, Mayo Clinic, Rochester, Minnesota, USA.
Eswari VilayurDepartment of Nephrology, John Hunter Hospital, Newcastle, Australia.
Gopala K RanganCentre for Transplant and Renal Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.
The University of Sydney · AUMayo Clinic · USGosford Hospital · AUPrincess Alexandra Hospital · AUWestmead Hospital · AUAustralian National University · AUJohn Hunter Hospital · AULiverpool Hospital · AUSt George Hospital · AUThe University of Western Australia · AUUniversity Medical Center · USUNSW Sydney · AUWollongong Hospital · AU

Funding

Pilot and FeasibilityP30DK090728 · NIDDK · MAYO CLINIC ROCHESTER · PI ROMERO, MICHAEL F. · 2010 to 2019
$11.8M
NIDDK NIH HHS P30 DK090728
6 · The paper itself

Abstract

introductionMaintaining fluid intake sufficient to reduce arginine vasopressin (AVP) secretion has been hypothesised to slow kidney cyst growth in autosomal dominant polycystic kidney disease (ADPKD). However, evidence to support this as a clinical practice recommendation is of poor quality. The aim of the present study is to determine the long-term efficacy and safety of prescribed water intake to prevent the progression of height-adjusted total kidney volume (ht-TKV) in patients with chronic kidney disease (stages 1-3) due to ADPKD. METHODS AND ANALYSIS: A multicentre, prospective, parallel-group, open-label, randomised controlled trial will be conducted. Patients with ADPKD (n=180; age ≤65 years, estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m ETHICS AND DISSEMINATION: The trial was approved by the Human Research Ethics Committee, Western Sydney Local Health District. The results will inform clinicians, patients and policy-makers regarding the long-term safety, efficacy and feasibility of prescribed fluid intake as an approach to reduce kidney cyst growth in patients with ADPKD. TRIAL REGISTRATION NUMBER: ANZCTR12614001216606.

Indexed as

DrinkingBlood PressureDisease ProgressionFluid TherapyGlomerular Filtration RateHumansKidneyKidney Failure, ChronicMagnetic Resonance ImagingOsmolar ConcentrationPolycystic Kidney, Autosomal DominantProspective StudiesText Messagingadult nephrologychronic renal failuremagnetic resonance imaging

Identifiers

PMID29358433
PMCPMC5780847
OpenAlexW2794771371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.