Evidence map›Paper›PMID 29358400›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Methyltransferases of gentamicin biosynthesis.

Sicong Li, Junhong Guo, Anna Reva, Fanglu Huang, Binbin Xiong, Yuanzhen Liu, Zixin Deng, Peter F Leadlay, Yuhui Sun

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 94 citations in OpenAlex.

  1. Article
  2. Article
  3. Effects ofAnimals : an open access journal from MDPI · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Glycodiversification of gentamicins throughActa pharmaceutica Sinica. B · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Sicong LiKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, People's Republic of China.
Junhong GuoKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, People's Republic of China.
Anna RevaDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.
Fanglu HuangDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.
Binbin XiongKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, People's Republic of China.
Yuanzhen LiuKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, People's Republic of China.
Zixin DengKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, People's Republic of China.
Peter F LeadlayDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom; yhsun@whu.edu.cn pfl10@cam.ac.uk.
Yuhui SunKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, People's Republic of China; yhsun@whu.edu.cn pfl10@cam.ac.uk.ORCID 0000-0001-5720-9620
Wuhan University · CNUniversity of Cambridge · GBShanghai Jiao Tong University · CN

Funding

Medical Research Council 1343325Medical Research Council G1001687Medical Research Council MR/M019020/1
6 · The paper itself

Abstract

Gentamicin C complex from

Indexed as

Bacterial ProteinsGene DeletionGentamicinsMethylationMethyltransferasesMicromonosporaMultigene FamilyMutationSpectrometry, Mass, Electrospray IonizationSubstrate SpecificityBacterial Proteinsgentamicin CGentamicinsMethyltransferasesaminoglycoside biosynthesisantibioticmetabolic engineeringmethyltransferase

Identifiers

PMID29358400
PMCPMC5819394
OpenAlexW2788603913

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.