Evidence map›Paper›PMID 29358396›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Centipedes subdue giant prey by blocking KCNQ channels.

Lei Luo, Bowen Li, Sheng Wang, Fangming Wu, Xiaochen Wang, Ping Liang, Rose Ombati, Junji Chen, Xiancui Lu, Jianmin Cui and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Inhibition Mechanism of Pancreatic KResearch (Washington, D.C.) · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Isolation and structural identification of a potassium ion channel Kv4.1 inhibitor SsTx-P2 from centipede venom.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Bioactive Peptides and Proteins from Centipede Venoms.Molecules (Basel, Switzerland) · 2022
    Review
  14. Centipede Venom: A Potential Source of Ion Channel Modulators.International journal of molecular sciences · 2022
    Review
  15. Linking toxicity and predation in a venomous arthropod: the case ofThe journal of venomous animals and toxins including tropical diseases · 2022
    Article
  16. Peptide OPTX-1 FromFrontiers in microbiology · 2021
    Article
  17. Peptide Toxins Targeting KV Channels.Handbook of experimental pharmacology · 2021
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 2 countries.

Lei LuoKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, Yunnan, China.
Bowen LiKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, Yunnan, China.
Sheng WangKey Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
Fangming WuHefei National Laboratory of Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
Xiaochen WangThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Ping LiangThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Rose OmbatiKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, Yunnan, China.
Junji ChenChongzhou People's Hospital, Sichuan Academy of Medical Sciences, Chengdu 611230, China.
Xiancui LuKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, Yunnan, China.
Jianmin CuiIon Channel Research and Drug Development Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Qiumin LuKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, Yunnan, China.
Longhua ZhangHefei National Laboratory of Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
Ming ZhouIon Channel Research and Drug Development Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; mzhou@bcm.edu cltian@ustc.edu.cn yangsl@mail.kiz.ac.cn rlai@mail.kiz.ac.cn.
Changlin TianHefei National Laboratory of Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China; mzhou@bcm.edu cltian@ustc.edu.cn yangsl@mail.kiz.ac.cn rlai@mail.kiz.ac.cn.
Shilong YangKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, Yunnan, China; mzhou@bcm.edu cltian@ustc.edu.cn yangsl@mail.kiz.ac.cn rlai@mail.kiz.ac.cn.
Ren LaiKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, Yunnan, China; mzhou@bcm.edu cltian@ustc.edu.cn yangsl@mail.kiz.ac.cn rlai@mail.kiz.ac.cn.
Chinese Academy of Sciences · CNHigh Magnetic Field Laboratory · CNKunming Institute of Zoology · CNFirst Affiliated Hospital Zhejiang University · CNHuazhong University of Science and Technology · CNSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · CNUniversity of Chinese Academy of Sciences · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Centipedes can subdue giant prey by using venom, which is metabolically expensive to synthesize and thus used frugally through efficiently disrupting essential physiological systems. Here, we show that a centipede (

Indexed as

AnimalsAnticonvulsantsArthropodsArthropod VenomsCarbamatesKCNQ Potassium ChannelsMiceNervous System DiseasesPhenylenediaminesPredatory BehaviorRespiratory System AbnormalitiesAnticonvulsantsArthropod VenomsCarbamatesezogabineKCNQ Potassium ChannelsPhenylenediaminescentipedeKCNQSsTxtoxicity

Identifiers

PMID29358396
PMCPMC5816164
OpenAlexW2784523653

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.