Evidence map›Paper›PMID 29358378›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Redirection of lipid flux toward phospholipids in yeast increases fatty acid turnover and secretion.

Raphael Ferreira, Paulo Gonçalves Teixeira, Verena Siewers, Jens Nielsen

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
  2. Engineering yeast for tailored fatty acid profiles.Applied microbiology and biotechnology · 2025
    Review
  3. Article
  4. Human Sterols Are Overproduced, Stored and Excreted in Yeasts.International journal of molecular sciences · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Using the inner membrane ofEngineering in life sciences · 2023
    Article
  9. Article
  10. Engineering caveolin-mediated endocytosis inSynthetic and systems biotechnology · 2022
    Article
  11. Article
  12. Article
  13. Overexpression ofInternational journal of molecular sciences · 2021
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Application of Random Mutagenesis and Synthetic FadR Promoter forFrontiers in bioengineering and biotechnology · 2021
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Raphael FerreiraDepartment of Biology and Biological Engineering, Chalmers University of Technology, SE412 96 Gothenburg, Sweden.ORCID 0000-0001-9881-6232
Paulo Gonçalves TeixeiraDepartment of Biology and Biological Engineering, Chalmers University of Technology, SE412 96 Gothenburg, Sweden.
Verena SiewersDepartment of Biology and Biological Engineering, Chalmers University of Technology, SE412 96 Gothenburg, Sweden.
Jens NielsenDepartment of Biology and Biological Engineering, Chalmers University of Technology, SE412 96 Gothenburg, Sweden; nielsenj@chalmers.se.
Chalmers University of Technology · SENovo Nordisk Foundation · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bio-based production of fatty acids and fatty acid-derived products can enable sustainable substitution of petroleum-derived fuels and chemicals. However, developing new microbial cell factories for producing high levels of fatty acids requires extensive engineering of lipid metabolism, a complex and tightly regulated metabolic network. Here we generated a

Indexed as

Lipid MetabolismAcyl-CoA OxidaseAcyl Coenzyme ACoenzyme A LigasesFatty AcidsGene DeletionGene Expression Regulation, FungalLysophospholipaseMembrane LipidsMembrane ProteinsPhosphatidate PhosphatasePhospholipidsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAcyl-CoA OxidaseAcyl Coenzyme ACoenzyme A LigasesFaa1 protein, S cerevisiaeFAA4 protein, S cerevisiaeFatty AcidsLysophospholipaseMembrane LipidsMembrane ProteinsPAH1 protein, S cerevisiaePhosphatidate PhosphatasePhospholipidsPLB1 protein, S cerevisiaePOX1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsCRISPRfree fatty acidsmetabolic engineeringphospholipidsSaccharomyces cerevisiae

Identifiers

PMID29358378
PMCPMC5819412
OpenAlexW2784900587

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.