ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Cortical Connections Position Primate Area 25 as a Keystone for Interoception, Emotion, and Memory.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed, 112 citations in OpenAlex.
- Preliminary evidence that ketamine alters anterior cingulate resting-state functional connectivity in depressed individuals.Translational psychiatry · 2023Trial
- Stimulation-evoked orbitofrontal activity as a biomarker for DBS personalization in depression.medRxiv : the preprint server for health sciences · 2026Article
- Categorization is 'baked' into the brain.Nature reviews. Neuroscience · 2026Review
- Internal connectivity of the mouse mesocortical ring and functional implications.Brain structure & function · 2026Article
- White matter pathways mediating dorsolateral prefrontal TMS therapy for depression.Nature neuroscience · 2026Article
- Annual Research Review: Neural mechanisms of eating disorders in youth - from current theory and findings to future directions.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- Comparing the Limbic-Frontal Connectome across the Primate Order: Conservation of Connections and Implications for Translational Neuroscience.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Shared and distinct alterations in brain connectivity and cognitive function in subthreshold and major depression.Psychological medicine · 2026Article
- Impairment of the GABAergic system in the prefrontal cortex of male heroin addicts.European archives of psychiatry and clinical neuroscience · 2026Article
- Review
- Episodic memory involves transient and sparse connectivity aligned to both internal and external events.PLoS biology · 2025Article
- Brain transcriptomic signatures for mood disorders and suicide phenotypes: an anterior insula and subgenual ACC network postmortem study.Brain, behavior, & immunity - health · 2025Article
- Dysfunction in primate dorsolateral prefrontal area 46 affects motivation and anxiety.Science (New York, N.Y.) · 2025Article
- Cortical circuit principles predict patterns of trauma induced tauopathy in humans.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- The Cortical Structural Model Extends to Thalamocortical Connections.The European journal of neuroscience · 2025Article
- Stress and Inflammation Target Dorsolateral Prefrontal Cortex Function: Neural Mechanisms Underlying Weakened Cognitive Control.Biological psychiatry · 2025Review
- Distortion of overlapping memories relates to arousal and anxiety.Cognitive, affective & behavioral neuroscience · 2025Article
- Altered parasympathetic outflow and central sensitization response to continuous pain in cyclic vomiting syndrome: a functional magnetic resonance imaging study.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
- Neural correlates of embodied and vibratory mechanisms associated with emotional prosody production.Social cognitive and affective neuroscience · 2025Article
- Anatomy and connectivity of the Göttingen minipig subgenual cortex (Brodmann area 25 homologue).Brain structure & function · 2024Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The structural and functional integrity of subgenual cingulate area 25 (A25) is crucial for emotional expression and equilibrium. A25 has a key role in affective networks, and its disruption has been linked to mood disorders, but its cortical connections have yet to be systematically or fully studied. Using neural tracers in rhesus monkeys, we found that A25 was densely connected with other ventromedial and posterior orbitofrontal areas associated with emotions and homeostasis. A moderate pathway linked A25 with frontopolar area 10, an area associated with complex cognition, which may regulate emotions and dampen negative affect. Beyond the frontal lobe, A25 was connected with auditory association areas and memory-related medial temporal cortices, and with the interoceptive-related anterior insula. A25 mostly targeted the superficial cortical layers of other areas, where broadly dispersed terminations comingled with modulatory inhibitory or disinhibitory microsystems, suggesting a dominant excitatory effect. The architecture and connections suggest that A25 is the consummate feedback system in the PFC. Conversely, in the entorhinal cortex, A25 pathways terminated in the middle-deep layers amid a strong local inhibitory microenvironment, suggesting gating of hippocampal output to other cortices and memory storage. The graded cortical architecture and associated laminar patterns of connections suggest how areas, layers, and functionally distinct classes of inhibitory neurons can be recruited dynamically to meet task demands. The complement of cortical connections of A25 with areas associated with memory, emotion, and somatic homeostasis provide the circuit basis to understand its vulnerability in psychiatric and neurologic disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.