ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Single-Cell Stimulation in Barrel Cortex Influences Psychophysical Detection Performance.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 40 citations in OpenAlex.
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- Network influence determines the impact of cortical ensembles on stimulus detection.bioRxiv : the preprint server for biology · 2024Article
- A latent pool of neurons silenced by sensory-evoked inhibition can be recruited to enhance perception.Neuron · 2024Article
- The influence of cortical activity on perception depends on behavioral state and sensory context.Nature communications · 2024Article
- Sparse and distributed cortical populations mediate sensorimotor integration.bioRxiv : the preprint server for biology · 2023Article
- Propagation of activity through the cortical hierarchy and perception are determined by neural variability.Nature neuroscience · 2023Article
- A systematic approach to brain dynamics: cognitive evolution theory of consciousness.Cognitive neurodynamics · 2023Article
- Cellular computation and cognition.Frontiers in computational neuroscience · 2023Article
- All-optical interrogation of neural circuits in behaving mice.Nature protocols · 2022Review
- Targeted photostimulation uncovers circuit motifs supporting short-term memory.Nature neuroscience · 2021Article
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- Precise Holographic Manipulation of Olfactory Circuits Reveals Coding Features Determining Perceptual Detection.Neuron · 2020Article
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- A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex.Cell reports · 2020Article
- Sensorimotor processing in the rodent barrel cortex.Nature reviews. Neuroscience · 2019Review
- Assessing the Impact of Single-Cell Stimulation on Local Networks in Rat Barrel Cortex-A Feasibility Study.International journal of molecular sciences · 2019Article
- Stimulation of Individual Neurons Is Sufficient to Influence Sensory-Guided Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Columnar Lesions in Barrel Cortex Persistently Degrade Object Location Discrimination Performance.eNeuroArticle
- Tonal Tinnitus Does Not Interfere with Tone Detection at the Tinnitus Pitch-Matched Frequency.Trends in hearingArticle
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
A single whisker stimulus elicits action potentials in a sparse subset of neurons in somatosensory cortex. The precise contribution of these neurons to the animal's perception of a whisker stimulus is unknown. Here we show that single-cell stimulation in rat barrel cortex of both sexes influences the psychophysical detection of a near-threshold whisker stimulus in a cell type-dependent manner, without affecting false alarm rate. Counterintuitively, stimulation of single fast-spiking putative inhibitory neurons increased detection performance. Single-cell stimulation of putative excitatory neurons failed to change detection performance, except for a small subset of deep-layer neurons that were highly sensitive to whisker stimulation and that had an unexpectedly strong impact on detection performance. These findings indicate that the perceptual impact of excitatory barrel cortical neurons relates to their firing response to whisker stimulation and that strong activity in a single highly sensitive neuron in barrel cortex can already enhance sensory detection. Our data suggest that sensory detection is based on a decoding mechanism that lends a disproportionally large weight to interneurons and to deep-layer neurons showing a strong response to sensory stimulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.