Evidence map›Paper›PMID 29358280›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1.

Jonathan H DeLong, Aisling O'Hara Hall, Christoph Konradt, Gaia M Coppock, Jeongho Park, Gretchen Harms Pritchard, Christopher A Hunter

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 71 citations in OpenAlex.

  1. CD8 T Cell Sensing of Type I Interferon Impacts Anergy.European journal of immunology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. CD4Nature immunology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. HEB Restrains Effector Gene Expression during Early CD8Molecular and cellular biology · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. IL-27 maintains cytotoxic Ly6CThe EMBO journal · 2024
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jonathan H DeLongDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-2032-8228
Aisling O'Hara HallImmunology Discovery Research, Janssen Research and Development, LLC, Spring House, PA 19002.
Christoph KonradtDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Gaia M CoppockDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Jeongho ParkDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Gretchen Harms PritchardDepartment of Immunology, University of Washington, Seattle, WA 98109.
Christopher A HunterDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104; chunter@vet.upenn.edu.
University of Pennsylvania · USJanssen (United States) · USUniversity of Washington · US

Funding

TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 1997 to 2026
$32.5M
TRAINING PROGRAM/RHEUMATIC DISEASEST32AR007442 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI BEHRENS, EDWARD M, MERKEL, PETER A · 1986 to 2018
$5.8M
Impact of early T-bet on CD8 T cell effector responsesR01AI125563 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HUNTER, CHRISTOPHER A · 2016 to 2020
$2.0M
IL-27 and Treg cellsR01AI110201 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HUNTER, CHRISTOPHER A · 2014 to 2018
$2.0M
NIAID NIH HHS R01 AI110201NIAID NIH HHS R01 AI125563NIAMS NIH HHS T32 AR007442NIDDK NIH HHS P30 DK050306
6 · The paper itself

Abstract

Ly6C and Sca-1 (Ly6A/E) are Ly6 family GPI-anchored surface molecules that are differentially expressed by multiple immune populations. Ly6C expression has been used to distinguish short-lived effector CD4

Indexed as

AnimalsAntigens, LyCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCytokinesFemaleMembrane ProteinsMiceMice, Inbred C57BLReceptors, Antigen, T-CellToxoplasmaToxoplasmosisAntigens, LyCytokinesLy6a protein, mouseLy-6C antigen, mouseMembrane ProteinsReceptors, Antigen, T-Cell

Identifiers

PMID29358280
PMCPMC5821564
OpenAlexW2784466101

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.