ArticleCirculation research2018
E2F1 Suppresses Oxidative Metabolism and Endothelial Differentiation of Bone Marrow Progenitor Cells.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Circulation research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
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- The Roles of Bone Marrow-Derived Stem Cells in Coronary Collateral Growth Induced by Repetitive Ischemia.Cells · 2023Article
- Exosomes Derived from E2F1International journal of nanomedicine · 2023Article
- NCAPD3 enhances Warburg effect through c-myc and E2F1 and promotes the occurrence and progression of colorectal cancer.Journal of experimental & clinical cancer research : CR · 2022Article
- The challenges and optimization of cell-based therapy for cardiovascular disease.Journal of translational internal medicine · 2021Review
- Metabolic reprogramming in cervical cancer and metabolomics perspectives.Nutrition & metabolism · 2021Review
- Analysis of mesenchymal stem cell proteomesTheranostics · 2020Article
- Sam68 impedes the recovery of arterial injury by augmenting inflammatory response.Journal of molecular and cellular cardiology · 2019Article
- Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentials.Blood advances · 2019Article
- The MTOR signaling pathway regulates macrophage differentiation from mouse myeloid progenitors by inhibiting autophagy.Autophagy · 2019Article
- CDCA5, Transcribed by E2F1, Promotes Oncogenesis by Enhancing Cell Proliferation and Inhibiting Apoptosis via the AKT Pathway in Hepatocellular Carcinoma.Journal of Cancer · 2019Article
- Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains.The Journal of clinical investigation · 2018Review
- Temporal Dynamics of Gene Expression During Endothelial Cell Differentiation From Human iPS Cells: A Comparison Study of Signalling Factors and Small Molecules.Frontiers in cardiovascular medicine · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
18 authors at 6 institutions in 2 countries.
Shiyue XuFrom the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.).
Jun TaoFrom the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.).
Liu YangFrom the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.).
Eric ZhangFrom the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.).
Chan BoribounFrom the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.).
Junlan ZhouFrom the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.).
Tianjiao SunFrom the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.).
Min ChengFrom the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.).
Kai HuangFrom the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.).
Jiawei ShiFrom the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.).
Nianguo DongFrom the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.).
Qinghua LiuFrom the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.).
Ting C ZhaoFrom the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.).
Hongyu QiuFrom the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.).
Robert A HarrisFrom the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.).
Navdeep S ChandelFrom the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.).
Douglas W LosordoFrom the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.).
Gangjian QinFrom the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.). gqin@uab.edu.
Huazhong University of Science and Technology · CNBoston University · USUnion Hospital · CNLoma Linda University · USProvidence College · USRoger Williams Medical Center · US
Funding
Tissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GR Scott Budinger · 2015 to 2026
$26.9MIntrinsic Stiffness of Aortic Vascular Smooth Muscle Cell in the Development of HypertensionR01HL115195 · NHLBI · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI QIU, HONGYU · 2013 to 2022
$5.1ME2F2 and Vascular FunctionR01HL138990 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NAKADA, YUJI · 2017 to 2020
$2.3MCXCR4 and ckit signaling in BM progenitor cell recruitment in the ischemic heartR01HL113541 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI QIN, GANGJIAN · 2012 to 2015
$1.5ME2F1 in Cardiac NeovascularizationR01HL093439 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI QIN, GANGJIAN · 2010 to 2013
$1.5ME2F1 in BM progenitor cell differentiation and cardiovascular repairR01HL131110 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI QIN, GANGJIAN, ZHAO, MING · 2016 to 2019
$1.5MNovel mechanisms mediating cardiac protection upon pressure overloadR56HL137962 · NHLBI · LOMA LINDA UNIVERSITY · PI QIU, HONGYU · 2017 to 2017
$393kNHLBI NIH HHS R01 HL093439NHLBI NIH HHS R01 HL113541NHLBI NIH HHS R01 HL115195NHLBI NIH HHS R01 HL131110NHLBI NIH HHS R01 HL138990NHLBI NIH HHS R56 HL137962NIA NIH HHS P01 AG049665
Abstract
rationaleThe majority of current cardiovascular cell therapy trials use bone marrow progenitor cells (BM PCs) and achieve only modest efficacy; the limited potential of these cells to differentiate into endothelial-lineage cells is one of the major barriers to the success of this promising therapy. We have previously reported that the E2F transcription factor 1 (E2F1) is a repressor of revascularization after ischemic injury.
objectiveWe sought to define the role of E2F1 in the regulation of BM PC function. METHODS AND
resultsAblation of E2F1 (E2F1 deficient) in mouse BM PCs increases oxidative metabolism and reduces lactate production, resulting in enhanced endothelial differentiation. The metabolic switch in E2F1-deficient BM PCs is mediated by a reduction in the expression of pyruvate dehydrogenase kinase 4 and pyruvate dehydrogenase kinase 2; overexpression of pyruvate dehydrogenase kinase 4 reverses the enhancement of oxidative metabolism and endothelial differentiation. Deletion of E2F1 in the BM increases the amount of PC-derived endothelial cells in the ischemic myocardium, enhances vascular growth, reduces infarct size, and improves cardiac function after myocardial infarction.
conclusionOur results suggest a novel mechanism by which E2F1 mediates the metabolic control of BM PC differentiation, and strategies that inhibit E2F1 or enhance oxidative metabolism in BM PCs may improve the effectiveness of cell therapy.
Indexed as
Cell DifferentiationOxidative StressAnimalsBone Marrow CellsBone Marrow TransplantationCells, CulturedE2F1 Transcription FactorEndothelial CellsMiceMyocardial InfarctionProtein KinasesProtein Serine-Threonine KinasesPyruvate Dehydrogenase Acetyl-Transferring KinaseE2f1 protein, mouseE2F1 Transcription FactorProtein KinasesProtein Serine-Threonine KinasesPyruvate Dehydrogenase Acetyl-Transferring Kinasepyruvate dehydrogenase kinase 4bone marrowcell differentiationendothelial progenitor cellsmyocardial infarctionoxygen consumptionstem cells
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