Evidence map›Paper›PMID 29358220›Full record

ReviewMolecular pharmacology2018

Caveolins as Regulators of Stress Adaptation.

Jan M Schilling, Brian P Head, Hemal H Patel

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Changes in cellular CaThe Journal of physiology · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jan M SchillingVeterans Administration San Diego Healthcare System and Department of Anesthesiology, UCSD School of Medicine, San Diego, California.
Brian P HeadVeterans Administration San Diego Healthcare System and Department of Anesthesiology, UCSD School of Medicine, San Diego, California.
Hemal H PatelVeterans Administration San Diego Healthcare System and Department of Anesthesiology, UCSD School of Medicine, San Diego, California hepatel@ucsd.edu.
VA San Diego Healthcare System · US

Funding

Vector Production CoreP01HL066941 · NHLBI · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI MIYANOHARA, ATSUSHI · 2001 to 2017
$34.8M
Caveolae, mitochondria, and cardiac protection.R01HL091071 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PATEL, HEMAL H · 2008 to 2019
$3.8M
Protection of the Aged MyocardiumR01HL107200 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PATEL, HEMAL H, ROTH, DAVID M · 2011 to 2014
$2.1M
Caveolae as capacitors for oxygenR21AG052722 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PATEL, HEMAL H · 2017 to 2018
$444k
Novel Therapeutics for Diabetic CardiomyopathyI01BX001963 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI PATEL, HEMAL H · 2013 to 2025
–
Caveolin-Mediated Neuroplasticity in Alzheimer's Disease and in Human Neurons Harboring EOFAD MutationsI01BX003671 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI HEAD, BRIAN P · 2017 to 2024
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BLRD VA I01 BX001963BLRD VA I01 BX003671NHLBI NIH HHS P01 HL066941NHLBI NIH HHS R01 HL091071NHLBI NIH HHS R01 HL107200NIA NIH HHS R21 AG052722
6 · The paper itself

Abstract

Caveolins have been recognized over the past few decades as key regulators of cell physiology. They are ubiquitously expressed and regulate a number of processes that ultimately impact efficiency of cellular processes. Though not critical to life, they are central to stress adaptation in a number of organs. The following review will focus specifically on the role of caveolin in stress adaptation in the heart, brain, and eye, three organs that are susceptible to acute and chronic stress and that show as well declining function with age. In addition, we consider some novel molecular mechanisms that may account for this stress adaptation and also offer potential to drive the future of caveolin research.

Indexed as

Adaptation, PhysiologicalAnimalsCaveolinsCell DeathCell Physiological PhenomenaCell ProliferationHumansOxidative StressStress, PhysiologicalCaveolins

Identifiers

PMID29358220
PMCPMC5820539
OpenAlexW2785195378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.