Evidence map›Paper›PMID 29358133›Full record

ArticleArchives of oral biology2018

Third molar agenesis as a potential marker for craniofacial deformities.

Clarissa Christina Avelar Fernandez, Christiane Vasconcellos Cruz Alves Pereira, Ronir Raggio Luiz, Italo M Faraco, Mary L Marazita, Maria Arnaudo, Flavia M de Carvalho, Fernando E Poletta, Juan C Mereb, Eduardo E Castilla and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Archives of oral biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Pulp enlargement in individuals born with cleft lip and palate pulp, a radiographic study from the cleft lip and palate service of paraiba, Brazil'.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021
    Article
  5. The Relationship between Agenesis of Third Molar and Craniofacial Morphology in Orthodontic Patients.Journal of International Society of Preventive & Community Dentistry
    Article
  6. A rare find of a maxillary third molar with five roots: a case report of an unusual morphology.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Clarissa Christina Avelar FernandezDepartment of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Christiane Vasconcellos Cruz Alves PereiraDepartment of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Ronir Raggio LuizInstitute for Studies in Public Health, IESC, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Italo M FaracoDepartment of Oral Biology and Center of Craniofacial and Dental Genetics, University of Pittsburgh School of Dental Medicine.
Mary L MarazitaECLAMC at CEMIC, Buenos Aires, Argentina.
Maria ArnaudoECLAMC at CEMIC, Buenos Aires, Argentina.
Flavia M de CarvalhoECLAMC at LEMC (Laboratory of Congenital Malformations Epidemiology), Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.
Fernando E PolettaECLAMC at CEMIC, Buenos Aires, Argentina.
Juan C MerebECLAMC at CEMIC, Buenos Aires, Argentina.
Eduardo E CastillaECLAMC at CEMIC, Buenos Aires, Argentina.
Iêda M OrioliECLAMC at Department of Genetics, Institute of Biology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Marcelo de Castro CostaDepartment of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Alexandre Rezende VieiraDepartment of Oral Biology and Center of Craniofacial and Dental Genetics, University of Pittsburgh School of Dental Medicine. Electronic address: alexandre_vieira@pitt.edu.
Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno · ARUniversidade Federal do Rio de Janeiro · BRUniversity of Pittsburgh · USFundação Oswaldo Cruz · BR

Funding

Extending the Phenotype of Nonsyndromic Orofacial CleftsR01DE016148 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L., WEINBERG, SETH M · 2004 to 2018
$19.7M
NIDCR NIH HHS R01 DE016148
6 · The paper itself

Abstract

The identification of clinical patterns of tooth agenesis in individuals born with craniofacial deformities may be a useful tool for risk determination of these defects. We hypothesize that specific craniofacial deformities are associated with third molar agenesis.

objectiveThe aim of this study was to identify if third molar agenesis could have a relation with other craniofacial structure alterations, such as cleft lip and palate, skeletal malocclusion, or specific growth patterns in humans.

designData were obtained from 550 individuals ascertained as part of studies aiming to identify genetic contributions to oral clefts. 831 dental records of patients aged over eight years seeking orthodontic treatment were also included. SN-GoGn angle were used to classify the growth pattern (hypo-divergent, normal and hyper-divergent), and the ANB angle was used to verify the skeletal malocclusion pattern (Class I, II and III). Panoramic radiographs were used to determine third molar agenesis.

resultsA high frequency of third molar agenesis among individuals born with cleft lip with or without cleft palate (55%), as well as among their relatives (93.5%) was found. Third molar agenesis was not associated to skeletal malocclusion or growth pattern.

conclusionIt appears that third molar agenesis is associated with the disturbances that lead to cleft lip and palate.

Indexed as

Abnormalities, MultipleAdolescentAdultAnodontiaBiomarkersChildCleft LipCleft PalateCraniofacial AbnormalitiesFemaleHumansMaleMalocclusionMandibleMaxillaMolar, ThirdBiomarkersCleft lip and palateCraniofacial deformitiesTooth agenesis

Identifiers

PMID29358133
PMCPMC6034603
OpenAlexW2785441491

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.