Evidence map›Paper›PMID 29357944›Full record

ArticleBMC research notes2018

Minimum values for midluteal plasma progesterone and estradiol concentrations in patients who achieved pregnancy with timed intercourse or intrauterine insemination without a human menopausal gonadotropin.

Yukiko Takaya, Hidehiko Matsubayashi, Kotaro Kitaya, Rie Nishiyama, Kohei Yamaguchi, Takumi Takeuchi, Tomomoto Ishikawa

Open access · goldAbstract read
In one paragraph

Article in BMC research notes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Endometrial Progesterone and Estrogen Receptors in Relation to Hormonal Levels in Women with Unexplained Recurrent Miscarriage.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2023
    Article
  4. Review
  5. Article
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yukiko TakayaReproduction Clinic Osaka, 15F, Grand Front Osaka Tower A4-20 Ofukacho, Kita, Osaka, 530-0011, Japan.
Hidehiko MatsubayashiReproduction Clinic Osaka, 15F, Grand Front Osaka Tower A4-20 Ofukacho, Kita, Osaka, 530-0011, Japan. matsubayashihide@me.com.ORCID http://orcid.org/0000-0002-6527-434X
Kotaro KitayaReproduction Clinic Osaka, 15F, Grand Front Osaka Tower A4-20 Ofukacho, Kita, Osaka, 530-0011, Japan.
Rie NishiyamaReproduction Clinic Osaka, 15F, Grand Front Osaka Tower A4-20 Ofukacho, Kita, Osaka, 530-0011, Japan.
Kohei YamaguchiReproduction Clinic Osaka, 15F, Grand Front Osaka Tower A4-20 Ofukacho, Kita, Osaka, 530-0011, Japan.
Takumi TakeuchiReproduction Clinic Osaka, 15F, Grand Front Osaka Tower A4-20 Ofukacho, Kita, Osaka, 530-0011, Japan.
Tomomoto IshikawaReproduction Clinic Osaka, 15F, Grand Front Osaka Tower A4-20 Ofukacho, Kita, Osaka, 530-0011, Japan.
Osaka Nishi Clinic · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of the study was to assess the lower limits of midluteal plasma progesterone and estradiol concentrations in patients who achieved pregnancy with timed intercourse or intrauterine insemination without a human menopausal gonadotropin stimulation.

resultsWe included 297 pregnant cycles of 297 women and assessed midluteal plasma progesterone and estradiol concentrations and pregnancy outcomes, retrospectively. These cycles were compared with the non-pregnant cycles (406 cycles) of the same women who became pregnant. Mean midluteal plasma P4 and E2 concentrations were significantly (P < 0.01) higher in pregnant cycles (14.5 and 188.5 pg/mL) than in non-pregnant cycles (10.7 and 162.6 pg/mL). The 5 percentiles of progesterone and estradiol in pregnant cycles were 5.6 and 70.2 pg/mL, respectively. The lowest progesterone and estradiol levels in pregnant cycles were 2.3 and 23.4 pg/mL, respectively. In non-pregnant cycles, many women had low P4 levels that were less than 5.6 ng/mL. Subgroup analyses showed slight differences among the four groups, which may have been due to the ovarian function of each group. Miscarriage was not related to progesterone and estradiol concentrations. These values may be useful for the evaluation of necessary values for pregnancy with timed intercourse or intrauterine insemination.

Indexed as

AdultCoitusEstradiolFemaleHumansInseminationLuteal PhaseMenotropinsOvulationPregnancyPregnancy OutcomeProgesteroneEstradiolMenotropinsProgesteroneEstradiolImplantationNatural cyclePregnancyProgesterone

Identifiers

PMID29357944
PMCPMC5778625
OpenAlexW2790317702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.