Evidence map›Paper›PMID 29357933›Full record

ArticleMicrobial cell factories2018

Metabolic flux analysis and the NAD(P)H/NAD(P)

Andres García, Pau Ferrer, Joan Albiol, Tania Castillo, Daniel Segura, Carlos Peña

Abstract read
In one paragraph

Article in Microbial cell factories, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Advances in alginate biosynthesis: regulation and production inFrontiers in bioengineering and biotechnology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Quantitative models of nitrogen-fixing organisms.Computational and structural biotechnology journal · 2020
    Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andres GarcíaDepartamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Col. Chamilpa Cuernavaca, Apdo. Post. 510-3, 62210, Cuernavaca, Morelos, Mexico.
Pau FerrerDepartament d'Engiyeria Química, Biològica i Ambiental, Escola d'Enginyeria, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallés), Barcelona, Spain.
Joan AlbiolDepartament d'Engiyeria Química, Biològica i Ambiental, Escola d'Enginyeria, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallés), Barcelona, Spain.
Tania CastilloDepartamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Col. Chamilpa Cuernavaca, Apdo. Post. 510-3, 62210, Cuernavaca, Morelos, Mexico.
Daniel SeguraDepartamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Col. Chamilpa Cuernavaca, 62210, Cuernavaca, Morelos, Mexico.
Carlos PeñaDepartamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Col. Chamilpa Cuernavaca, Apdo. Post. 510-3, 62210, Cuernavaca, Morelos, Mexico. carlosf@ibt.unam.mx.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAzotobacter vinelandii is a bacterium that produces alginate and polyhydroxybutyrate (P3HB); however, the role of NAD(P)H/NAD(P)

resultsThe results reveal that changes in the oxygen availability have an important effect on the metabolic fluxes and intracellular NADPH/NADP

conclusionsWe have demonstrated that changes in oxygen availability affect the internal redox state of the cell and carbon metabolic fluxes. This also has a strong impact on the TCA cycle and PP pathway as well as on alginate and P3HB biosynthetic fluxes.

Indexed as

Metabolic Flux AnalysisAlginatesAzotobacter vinelandiiBiomassBiosynthetic PathwaysCarbonCitric Acid CycleCulture MediaNADNADPOxidation-ReductionOxygenPentose Phosphate PathwayAlginatesCarbonCulture MediaNADNADPOxygenAzotobacter vinelandiiMetabolic flux analysisNAD(P)H/NAD(P)+ ratiosOxygen availability

Identifiers

PMID29357933
PMCPMC5776761

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.