Evidence map›Paper›PMID 29357833›Full record

ArticleBMC genomics2018

Genome-wide DNA methylation profiling in whole blood reveals epigenetic signatures associated with migraine.

Zachary F Gerring, Allan F McRae, Grant W Montgomery, Dale R Nyholt

Registry-linked trialOpen access · goldAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04503083 (A Multidisciplinary Approach to the Identification of BIOmarkers of MIGraine), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04503083 completednot on this mapstarted 2021, after this paper: background citation

A Multidisciplinary Approach to the Identification of BIOmarkers of MIGraine: a Proof of Concept Study Based on the Stratification of Responders to CGRP Monoclonal Antibodies

TypeobservationalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2021 to 2024Enrolled243ConditionsMigraine
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. The Power ofCurrent issues in molecular biology · 2024
    Article
  11. Review
  12. Article
  13. The Epigenetics of Migraine.International journal of molecular sciences · 2023
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Exploring the Hereditary Nature of Migraine.Neuropsychiatric disease and treatment · 2021
    Review
  19. Review
  20. Genetics of migraine aura: an update.The journal of headache and pain · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Zachary F GerringStatistical and Genomic Epidemiology Laboratory, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia. zac.gerring@gmail.com.
Allan F McRaeInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Grant W MontgomeryInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Dale R NyholtStatistical and Genomic Epidemiology Laboratory, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Queensland University of Technology · AUUniversity of Queensland · AU

Funding

EUROHEADPAIN 602633National Health and Medical Research Council APP1046880National Health and Medical Research Council APP1075175National Health and Medical Research Council APP1083405
6 · The paper itself

Abstract

backgroundMigraine is a common heritable neurovascular disorder typically characterised by episodic attacks of severe pulsating headache and nausea, often accompanied by visual, auditory or other sensory symptoms. Although genome-wide association studies have identified over 40 single nucleotide polymorphisms associated with migraine, there remains uncertainty about the casual genes involved in disease pathogenesis and how their function is regulated.

resultsWe performed an epigenome-wide association study, quantifying genome-wide patterns of DNA methylation in 67 migraine cases and 67 controls with a matching age and sex distribution. Association analyses between migraine and methylation probe expression, after adjustment for cell type proportions, indicated an excess of small P values, but there was no significant single-probe association after correction for multiple testing (P < 1.09 × 10

conclusionsThis study represents the first genome-wide analysis of DNA methylation in migraine. We have identified DNA methylation in the whole blood of subjects associated with migraine, highlighting novel loci that provide insight into the biological pathways and mechanisms underlying migraine pathogenesis.

Indexed as

DNA MethylationEpigenomicsGenetic MarkersGenome, HumanAdolescentAdultAgedCase-Control StudiesChildFemaleGenome-Wide Association StudyHumansMaleMiddle AgedMigraine DisordersPolymorphism, Single NucleotideGenetic MarkersBloodDifferentialMethylationMigraine

Identifiers

PMID29357833
PMCPMC5778740
OpenAlexW2792783603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.