ArticleBMC pediatrics2018
Caffeine is a risk factor for osteopenia of prematurity in preterm infants: a cohort study.
Article in BMC pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Pooled it
- Review
- Postnatal Steroids in Preterm Infants: A Narrative Review Series-Part 3: Impacts on Growth, Neurodevelopment & Nutrition.Children (Basel, Switzerland) · 2026Review
- Association Between Serum Caffeine Concentrations, Intermittent Hypoxia and Apnea in Preterm Infants: A Prospective Observational Study.Children (Basel, Switzerland) · 2026Article
- Invited Mini Review Metabolic Bone Disease of Prematurity: Overview and Practice Recommendations.Hormone research in paediatrics · 2025Review
- Predictors for poor daily weight gain in preterm neonates exposed to different dose regimens of caffeine in ICU- a retrospective cohort study.BMC pediatrics · 2024Article
- Caffeine versus other methylxanthines for the prevention and treatment of apnea in preterm infants.The Cochrane database of systematic reviews · 2023Review
- Soft drinks, tea and coffee consumption in relation to risk of fracture: evidence from china health and nutrition survey.Journal of bone and mineral metabolism · 2023Article
- Diagnosis and management of mineral and bone disorders in infants with CKD: clinical practice points from the ESPN CKD-MBD and Dialysis working groups and the Pediatric Renal Nutrition Taskforce.Pediatric nephrology (Berlin, Germany) · 2023Review
- Relationship of caffeine regimen with osteopenia of prematurity in preterm neonates: a cohort retrospective study.BMC pediatrics · 2022Article
- Treating Apnea of Prematurity.Cureus · 2022Review
- Is quantitative ultrasound a measure for metabolic bone disease in preterm-born infants? A prospective subcohort study.European journal of pediatrics · 2021Article
- [Risk factors for metabolic bone disease of prematurity in very/extremely low birth weight infants: a multicenter investigation in China].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- Femur Fracture in a Premature Infant: An Unusual Association of Sickle Cell Disease with Osteogenesis Imperfecta.The American journal of case reports · 2020Article
- Long bone fractures in neonatal intensive care units of Afyonkarahisar: Five-year's experience.Turkish journal of obstetrics and gynecology · 2019Article
- Caffeine Treatment for Apnea of Prematurity and the Influence on Dose-Dependent Postnatal Weight Gain Observed Over 15 Years.Journal of caffeine and adenosine research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCaffeine, the most commonly used medication in Neonatal Intensive Care Units, has calciuric and osteoclastogenic effects.
methodsTo examine the association between the cumulative dose and duration of therapy of caffeine and osteopenia of prematurity, a retrospective cohort study was conducted including premature infants less than 31 weeks and birth weight less than 1500 g. Osteopenia of prematurity was evaluated using chest X-rays on a biweekly basis over 12 weeks of hospitalization.
resultsThe cohort included 109 infants. 51% had osteopenia of prematurity and 8% had spontaneous rib fractures. Using the generalized linear mixed model, caffeine dose and duration of caffeine therapy showed a strong association with osteopenia of prematurity. Steroids and vitamin D were also significantly correlated with osteopenia of prematurity while diuretic use did not show a statistically significant effect.
conclusionThe cumulative dose and duration of therapy of caffeine, as well as steroid are associated with osteopenia of prematurity in this cohort. Future studies are needed to confirm these findings and determine the lowest dose of caffeine needed to treat effectively apnea of prematurity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.