Evidence map›Paper›PMID 29357817›Full record

ArticleBMC bioinformatics2018

Feature selection for high-dimensional temporal data.

Michail Tsagris, Vincenzo Lagani, Ioannis Tsamardinos

Abstract read
In one paragraph

Article in BMC bioinformatics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Longitudinal omics data analysis: approaches and applications.Computational and structural biotechnology journal · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michail TsagrisDepartment of Computer Science, University of Crete, Voutes Campus, Heraklion, 70013, Greece. mtsagris@csd.uoc.gr.ORCID 0000-0002-2049-3063
Vincenzo LaganiDepartment of Computer Science, University of Crete, Voutes Campus, Heraklion, 70013, Greece.
Ioannis TsamardinosDepartment of Computer Science, University of Crete, Voutes Campus, Heraklion, 70013, Greece.

Funding

European Research Council 617393
6 · The paper itself

Abstract

backgroundFeature selection is commonly employed for identifying collectively-predictive biomarkers and biosignatures; it facilitates the construction of small statistical models that are easier to verify, visualize, and comprehend while providing insight to the human expert. In this work we extend established constrained-based, feature-selection methods to high-dimensional "omics" temporal data, where the number of measurements is orders of magnitude larger than the sample size. The extension required the development of conditional independence tests for temporal and/or static variables conditioned on a set of temporal variables.

resultsThe algorithm is able to return multiple, equivalent solution subsets of variables, scale to tens of thousands of features, and outperform or be on par with existing methods depending on the analysis task specifics.

conclusionsThe use of this algorithm is suggested for variable selection with high-dimensional temporal data.

Indexed as

AlgorithmsGenomicsLinear ModelsLongitudinal dataMultiple solutionsRegressionTime course dataVariable selection

Identifiers

PMID29357817
PMCPMC5778658

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.