ArticlePharmaceutical biology2018
Effects of glycyrrhizin on the pharmacokinetics of asiatic acid in rats and its potential mechanism.
Article in Pharmaceutical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Cationic biopolymer decorated Asiatic Acid andF1000Research · 2022Article
- Influence of verapamil on the pharmacokinetics of rotundic acid in rats and its potential mechanism.Pharmaceutical biology · 2021Article
- Pogostone inhibits the activity of CYP3A4, 2C9, and 2E1Pharmaceutical biology · 2021Article
- Review
- Potential Herb-Drug Interactions in the Management of Age-Related Cognitive Dysfunction.Pharmaceutics · 2021Review
- Effects of curcumin on the pharmacokinetics of amlodipine in rats and its potential mechanism.Pharmaceutical biology · 2020Article
- Effects of glycyrrhizin on the pharmacokinetics of nobiletin in rats and its potential mechanism.Pharmaceutical biology · 2020Article
- Effects of glycyrrhizin on the pharmacokinetics of paeoniflorin in rats and its potential mechanism.Pharmaceutical biology · 2019Article
- Influence of verapamil on the pharmacokinetics of oridonin in rats.Pharmaceutical biology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextAsiatic acid has been reported to possess a wide range of pharmacological activities.
objectiveThis study investigates the effects of glycyrrhizin on the pharmacokinetics of asiatic acid in rats and its potential mechanism. MATERIALS AND
methodsThe pharmacokinetics of orally administered asiatic acid (20 mg/kg) with or without glycyrrhizin pretreatment (100 mg/kg/day for seven days) were investigated using a LC-MS method. Additionally, the Caco-2 cell transwell model and rat liver microsome incubation systems were used to investigate the potential mechanism of glycyrrhizin's effects on the pharmacokinetics of asiatic acid.
resultsThe results showed that the C DISCUSSION AND
conclusionsIn conclusion, these results indicated that glycyrrhizin could decrease the system exposure of asiatic acid, possibly by inducing the activity of P-gp or CYP450 enzyme.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.