ArticleJournal of neurophysiology2018
Robust and tunable bursting requires slow positive feedback.
Article in Journal of neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 1 citations in OpenAlex.
- Activity-dependent neuromodulation and calcium homeostasis cooperate to produce robust and modulable neuronal function.PLoS computational biology · 2026Article
- Quantitative prediction of intracellular dynamics and synaptic currents in a small neural circuit.Frontiers in computational neuroscience · 2025Article
- Dimensionality reduction of neuronal degeneracy reveals two interfering physiological mechanisms.PNAS nexus · 2024Article
- A novel mechanism for ramping bursts based on slow negative feedback in model respiratory neurons.Chaos (Woodbury, N.Y.) · 2024Article
- Slow negative feedback enhances robustness of square-wave bursting.Journal of computational neuroscience · 2023Article
- Article
- Robust switches in thalamic network activity require a timescale separation between sodium and T-type calcium channel activations.PLoS computational biology · 2021Article
- The geometry of rest-spike bistability.Journal of mathematical neuroscience · 2020Article
- Circuit Stability to Perturbations Reveals Hidden Variability in the Balance of Intrinsic and Synaptic Conductances.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Co-opting evo-devo concepts for new insights into mechanisms of behavioural diversity.The Journal of experimental biology · 2019Review
- M current regulates firing mode and spike reliability in a collision-detecting neuron.Journal of neurophysiology · 2018Article
- Switchable slow cellular conductances determine robustness and tunability of network states.PLoS computational biology · 2018Article
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We highlight that the robustness and tunability of a bursting model critically rely on currents that provide slow positive feedback to the membrane potential. Such currents have the ability to make the total conductance of the circuit negative in a timescale that is termed "slow" because it is intermediate between the fast timescale of the spike upstroke and the ultraslow timescale of even slower adaptation currents. We discuss how such currents can be assessed either in voltage-clamp experiments or in computational models. We show that, while frequent in the literature, mathematical and computational models of bursting that lack the slow negative conductance are fragile and rigid. Our results suggest that modeling the slow negative conductance of cellular models is important when studying the neuromodulation of rhythmic circuits at any broader scale. NEW & NOTEWORTHY Nervous system functions rely on the modulation of neuronal activity between different rhythmic patterns. The mechanisms of this modulation are still poorly understood. Using computational modeling, we show the critical role of currents that provide slow negative conductance, distinct from the fast negative conductance necessary for spike generation. The significance of the slow negative conductance for neuromodulation is often overlooked, leading to computational models that are rigid and fragile.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.