ArticleJournal of neurophysiology2018
Impact of light-adaptive mechanisms on mammalian retinal visual encoding at high light levels.
Article in Journal of neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Temporal prediction captures retinal spiking responses across animal species.Nature communications · 2026Article
- Adaptation of visual responses in degeneratingFrontiers in neuroscience · 2026Article
- Asymmetric activation of retinal ON and OFF pathways by AOSLO raster-scanned visual stimuli.Biomedical optics express · 2025Article
- Human Electroretinography Shows Little Polarity Specificity Following Full-Field Ramp Adaptation.Investigative ophthalmology & visual science · 2024Article
- Melanopsin-mediated amplification of cone signals in the human visual cortex.Proceedings. Biological sciences · 2024Article
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- Solo vs. Chorus: Monomers and Oligomers of Arrestin Proteins.International journal of molecular sciences · 2022Review
- Retinal horizontal cells use different synaptic sites for global feedforward and local feedback signaling.Current biology : CB · 2022Article
- Inhibition, but not excitation, recovers from partial cone loss with greater spatiotemporal integration, synapse density, and frequency.Cell reports · 2022Article
- Temporal vision: measures, mechanisms and meaning.The Journal of experimental biology · 2021Article
- Rod Photoreceptors Avoid Saturation in Bright Light by the Movement of the G Protein Transducin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Inhibitory components of retinal bipolar cell receptive fields are differentially modulated by dopamine D1 receptors.Visual neuroscience · 2020Article
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Authors and funding
3 authors.
Funding
Abstract
A persistent change in illumination causes light-adaptive changes in retinal neurons. Light adaptation improves visual encoding by preventing saturation and by adjusting spatiotemporal integration to increase the signal-to-noise ratio (SNR) and utilize signaling bandwidth efficiently. In dim light, the visual input contains a greater relative amount of quantal noise, and vertebrate receptive fields are extended in space and time to increase SNR. Whereas in bright light, SNR of the visual input is high, the rate of synaptic vesicle release from the photoreceptors is low so that quantal noise in synaptic output may limit SNR postsynaptically. Whether and how reduced synaptic SNR impacts spatiotemporal integration in postsynaptic neurons remains unclear. To address this, we measured spatiotemporal integration in retinal horizontal cells and ganglion cells in the guinea pig retina across a broad illumination range, from low to high photopic levels. In both cell types, the extent of spatial and temporal integration changed according to an inverted U-shaped function consistent with adaptation to low SNR at both low and high light levels. We show how a simple mechanistic model with interacting, opponent filters can generate the observed changes in ganglion cell spatiotemporal receptive fields across light-adaptive states and postulate that retinal neurons postsynaptic to the cones in bright light adopt low-pass spatiotemporal response characteristics to improve visual encoding under conditions of low synaptic SNR.
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