Evidence map›Paper›PMID 29357426›Full record

ArticleAmerican journal of physiology. Renal physiology2018

Divergent roles for kidney proximal tubule and granulocyte PAD4 in ischemic AKI.

Hongmei Li, Sang Jun Han, Mihwa Kim, Ahyeon Cho, Yewoon Choi, Vivette D'Agati, H Thomas Lee

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Norepinephrine released by intestinal Paneth cells exacerbates ischemic AKI.American journal of physiology. Renal physiology · 2020
    Article
  8. Review
  9. Peptidyl arginine deiminase-4 exacerbates ischemic AKI by finding NEMO.American journal of physiology. Renal physiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hongmei LiDepartment of Anesthesiology, College of Physicians and Surgeons of Columbia University , New York, New York.
Sang Jun HanDepartment of Anesthesiology, College of Physicians and Surgeons of Columbia University , New York, New York.
Mihwa KimDepartment of Anesthesiology, College of Physicians and Surgeons of Columbia University , New York, New York.
Ahyeon ChoDepartment of Anesthesiology, College of Physicians and Surgeons of Columbia University , New York, New York.
Yewoon ChoiDepartment of Anesthesiology, College of Physicians and Surgeons of Columbia University , New York, New York.
Vivette D'AgatiDepartment of Pathology, College of Physicians and Surgeons of Columbia University , New York, New York.
H Thomas LeeDepartment of Anesthesiology, College of Physicians and Surgeons of Columbia University , New York, New York.
Columbia University · US

Funding

Paneth cells and acute kidney injuryR01DK109544 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEE, H. THOMAS · 2017 to 2021
$1.8M
Peptidylarginine deiminase-4 and acute kidney injuryR01DK115694 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEE, H. THOMAS · 2017 to 2021
$1.6M
NIDDK NIH HHS R01 DK109544NIDDK NIH HHS R01 DK115694
6 · The paper itself

Abstract

We previously demonstrated that kidney peptidylarginine deiminase-4 (PAD4) plays a critical role in ischemic acute kidney injury (AKI) in mice by promoting renal tubular inflammation and neutrophil infiltration (Ham A, Rabadi M, Kim M, Brown KM, Ma Z, D'Agati V, Lee HT. Am J Physiol Renal Physiol 307: F1052-F1062, 2014). Although the role of PAD4 in granulocytes including neutrophils is well known, we surprisingly observed profound renal proximal tubular PAD4 induction after renal ischemia-reperfusion (I/R) injury. Here we tested the hypothesis that renal proximal tubular PAD4 rather than myeloid-cell lineage PAD4 plays a critical role in exacerbating ischemic AKI by utilizing mice lacking PAD4 in renal proximal tubules (PAD4

Indexed as

ApoptosisNeutrophil InfiltrationAcute Kidney InjuryAnimalsCytokinesHydrolasesInflammation MediatorsKidney Tubules, ProximalMice, Inbred C57BLMice, KnockoutNeutrophilsProtein-Arginine Deiminase Type 4Reperfusion InjurySignal TransductionCytokinesHydrolasesInflammation Mediatorspeptidylarginine deiminase 4, mouseProtein-Arginine Deiminase Type 4apoptosisinflammationischemia and reperfusion injurynecrosisneutrophil

Identifiers

PMID29357426
PMCPMC6031910
OpenAlexW2781564526

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.