ArticlePloS one2018
Impact of chronic exposure to the pesticide chlorpyrifos on respiratory parameters and sleep apnea in juvenile and adult rats.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Is exposure to chemical pollutants associated with sleep outcomes? A systematic review.Sleep medicine reviews · 2023Pooled it
- Chlorpyrifos and Chlorpyrifos-Oxon: A Widening Spectrum of Toxicity.International journal of molecular sciences · 2026Review
- PMToxics · 2026Article
- Long lasting effects of perinatal exposure to the Chlorpyrifos pesticide on sleep, breathing, and neuroinflammation in adult mice.PloS one · 2025Article
- Diazinon-induced Cognitive Impairment: Alternations in Amyloid Precursor Proteins, and TNF-α Expression in the Hippocampus of Adult Rats.Current topics in medicinal chemistry · 2025Article
- The effect of chlorpyrifos oral exposure on the histomorphometric and kidney function in Wistar rat.Indian journal of pharmacology · 2024Article
- Exposure to Chlorpyrifos Alters Proliferation, Differentiation and Fatty Acid Uptake in 3T3-L1 Cells.International journal of molecular sciences · 2023Article
- Disparities in Sleep-Disordered Breathing: Upstream Risk Factors, Mechanisms, and Implications.Clinics in chest medicine · 2023Review
- Impact of Pesticide Residues on the Gut-Microbiota-Blood-Brain Barrier Axis: A Narrative Review.International journal of molecular sciences · 2023Review
- Endocrine disrupting chemicals and male fertility: from physiological to molecular effects.Frontiers in public health · 2023Review
- Consumption of Pila globosa (Swainson) collected from organophosphate applied paddy fields: human health risks.Environmental science and pollution research international · 2022Article
- Prenatal maternal pesticide exposure in relation to sleep health of offspring during adolescence.Environmental research · 2022Article
- The Effect of Residential Environment on Respiratory Diseases and Pulmonary Function in Children from a Community in Jilin Province of China.Risk management and healthcare policy · 2021Article
- Sleep in honey bees is affected by the herbicide glyphosate.Scientific reports · 2020Article
- Determination of CHLORPYRIFOS by GC/ECD in water and its sorption mechanism study in a RHODIC FERRALSOL.Journal of environmental health science & engineering · 2020Article
- Health status among greenhouse workers exposed to different levels of pesticides: A genetic matching analysis.Scientific reports · 2020Article
- Data on dysfunctional muscle contraction and genes contractile expression associated with chlorpyrifos exposure in slow twitch skeletal muscle.Data in brief · 2019Article
- Impacts of prolonged chlorpyrifos exposure on locomotion and slow-and fast- twitch skeletal muscles contractility in rats.Toxicology reports · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The widely used organophosphorus pesticide chlorpyrifos (CPF) is often detected in food. CPF inhibits acetylcholinesterase and can modify muscle contractility and respiratory patterns. We studied the effects of chronic exposure to CPF on respiratory parameters and diaphragm contractility in 21- and 60-days old rats. Pregnant rats were exposed to oral CPF (1 or 5 mg/ kg /day: CPF-1 or CPF-5 groups vs vehicle: controls) from gestation onset up to weaning of the pups that were individually gavaged (CPF or vehicle) thereafter. Two developmental time points were studied: weaning (day 21) and adulthood (day 60). Whole-body plethysmography was used to score breathing patterns and apnea index during sleep. Then, diaphragm strips were dissected for the assessment of contractility and acetylcholinesterase activity. Results showed that the sleep apnea index was higher in CPF-exposed rats than in controls. In adult rats, the expiratory time and tidal volume were higher in CPF-exposed animals than in controls. At both ages, the diaphragm's amplitude of contraction and fatigability index were higher in the CPF-5 group, due to lower acetylcholinesterase activity. We conclude that chronic exposure to CPF is associated with higher sleep apnea index and diaphragm contractility, and modifies respiratory patterns in sleeping juvenile and adult rats.
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