ArticleJournal of clinical hypertension (Greenwich, Conn.)2018
Framingham Stroke Risk Profile is related to cerebral small vessel disease progression and lower cognitive performance in patients with hypertension.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- The effect of community intervention based on deep learning-established early screening system and model construction for stroke.BMC neurology · 2026Article
- Methods of a Study to Assess the Contribution of Cerebral Small Vessel Disease and Dementia Risk Alleles to Racial Disparities in Vascular Cognitive Impairment and Dementia.Journal of the American Heart Association · 2023Article
- The value of mobile magnetic resonance imaging in early warning for stroke: A prospective case-control study.Frontiers in neuroscience · 2022Article
- Study on the Interaction between the Characteristics of Retinal Microangiopathy and Risk Factors for Cerebral Small Vessel Disease.Contrast media & molecular imaging · 2022Article
- Breast Arterial Calcification Is Not Associated with Mild Cognitive Impairment or Incident All-Cause Dementia Among Postmenopausal Women: The MINERVA Study.Journal of women's health (2002) · 2021Article
- Association of midlife stroke risk with structural brain integrity and memory performance at older ages: a longitudinal cohort study.Brain communications · 2020Article
- Revised Framingham Stroke Risk Profile: Association with Cognitive Status and MRI-Derived Volumetric Measures.Journal of Alzheimer's disease : JAD · 2020Article
- Vascular burden and APOE ε4 are associated with white matter microstructural decline in cognitively normal older adults.NeuroImage · 2019Article
- The Altered Reconfiguration Pattern of Brain Modular Architecture Regulates Cognitive Function in Cerebral Small Vessel Disease.Frontiers in neurology · 2019Article
- The importance of comorbidities in ischemic stroke: Impact of hypertension on the cerebral circulation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Review
- Cerebral Microbleeds in Advanced Dementia: Clinical and Pathological Correlates.American journal of Alzheimer's disease and other dementias · 2018Article
- Plasma brain natriuretic peptide is a biomarker for screening ischemic cerebral small vessel disease in patients with hypertension.Medicine · 2018Article
- Framingham Stroke Risk Profile is related to cerebral small vessel disease progression and lower cognitive performance in patients with hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Searching cerebrovascular risk indicators for hypertensive patients: Is Framingham Stroke Risk Profile "the magic bullet"?Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Modified Framingham stroke risk profile and related research on uric acid in individuals aged over 65 years in the Yangtze River Delta region, China.Frontiers in neurologyArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Framingham Stroke Risk Profile (FSRP) was developed to predict clinical stroke. We investigated if FSRP is associated with more "silent" effects of cerebrovascular disease, namely progression of cerebral small vessel disease (cSVD)-related brain damage and cognitive performance in hypertensive patients. Ninety patients with essential hypertension underwent a brain MRI scan and FSRP assessment at baseline, and a second brain MRI scan and neuropsychological assessment at 9-year follow-up. We visually rated progression of cSVD-related MRI markers. FSRP was associated with progressive periventricular white matter hyperintensities (P = .017) and new microbleeds (P = .031), but not after correction for the FSRP age component. FSRP was associated with lower overall cognitive performance (P < .001) and this remained significant after correction for the FSRP age component. A vascular risk score might be useful in predicting progression of cSVD-related brain damage or future cognitive performance in hypertensive patients. Age seems to be the most important component in FSRP.
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