Evidence map›Paper›PMID 29356970›Full record

ArticleJournal of neurology2018

Cognitive phenotypes in multiple sclerosis.

Victoria M Leavitt, Gabriella Tosto, Claire S Riley

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
  4. Observational
  5. Article
  6. Language dysfunction as a primary feature of cognitive decline in neurological populations.Journal of neural transmission (Vienna, Austria : 1996) · 2026
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  13. Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Victoria M LeavittDepartment of Neurology, Columbia University Medical Center, 630 W. 168th Street, New York, NY, 10032, USA. VL2337@cumc.columbia.edu.ORCID http://orcid.org/0000-0001-8937-6079
Gabriella TostoDepartment of Neurology, Columbia University Medical Center, 630 W. 168th Street, New York, NY, 10032, USA.
Claire S RileyDepartment of Neurology, Columbia University Medical Center, 630 W. 168th Street, New York, NY, 10032, USA.

Funding

National Multiple Sclerosis Society (US) RG-4810A1/1
6 · The paper itself

Abstract

backgroundCognitive impairment is a debilitating symptom experienced by ~ 50% of multiple sclerosis patients, with processing speed (PS) and memory most affected. Until now, the field has considered cognition in a binary fashion: patients are designated as impaired or not impaired. This designation is typically arrived at by administering a full cognitive battery and assigning a cutoff (e.g., 4 of 11 tests failed) to distinguish impaired/non-impaired. This relatively coarse approach yields a heterogeneous group of "impaired" patients, some of whom may have isolated memory or PS deficits, others with combined deficits. The goal of this study is to determine whether predominant patterns of deficits, "cognitive phenotypes", can be identified in a large sample of MS patients. Proportional representation of four cognitive phenotypes will be evaluated: (1) not impaired, (2) PS-impaired only, (3) memory-impaired only, (4) PS + memory impaired.

methodsCognition was measured in 128 relapsing-remitting MS patients using validated tests of verbal/visual memory, and PS. Cognitive phenotype representation was evaluated. Differences in age, education, disease duration, and IQ across cognitive phenotype groups were evaluated.

resultsFour cognitive phenotype groups were represented: 56.3% not impaired, 7.8% PS-impaired, 18.8% memory-impaired, 17.2% PS + memory impaired. Across groups, there were no differences in age, education, disease duration. IQ in non-impaired was higher than PS + memory impaired.

conclusionsAdopting a novel classification taxonomy for cognitive phenotypes will advance understanding of cognitive impairment and enable a precision medicine approach to the development of effective, targeted treatments for cognition in persons with MS.

Indexed as

CognitionAdultAge FactorsCognition DisordersDisease ProgressionEducational StatusFemaleHumansMaleMultiple Sclerosis, Relapsing-RemittingNeuropsychological TestsPhenotypeTime FactorsCognitionCognitive impairmentMultiple sclerosisNeuropsychology

Identifiers

PMID29356970

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.