Evidence map›Paper›PMID 29356966›Full record

ReviewCurrent hypertension reports2018

Pheochromocytomas and Hypertension.

Joseph M Pappachan, Nyo Nyo Tun, Ganesan Arunagirinathan, Ravinder Sodi, Fahmy W F Hanna

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current hypertension reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Navigating the Complexities of Cancer Treatment-Induced Hypertension.Journal of cardiovascular development and disease · 2025
    Review
  7. Article
  8. Article
  9. Inflammation-based Scores in Patients With Pheochromocytoma.The Journal of clinical endocrinology and metabolism · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Weakly supervised detection of pheochromocytomas and paragangliomas in CT using noisy data.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2024
    Article
  15. Selective venous sampling for secondary hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Joseph M PappachanDepartment of Endocrinology and Metabolism, University Hospitals of Morecambe Bay NHS Foundation Trust, Lancaster, LA1 4RP, UK. drpappachan@yahoo.co.in.
Nyo Nyo TunMetabolic Unit, Western General Hospital, Edinburgh, UK.
Ganesan ArunagirinathanMetabolic Unit, Western General Hospital, Edinburgh, UK.
Ravinder SodiDepartment of Biochemistry and Blood Sciences, University Hospitals of Morecambe Bay NHS Foundation Trust, Lancaster, LA1 4RP, UK.
Fahmy W F HannaDepartment of Endocrinology and Metabolism, The Royal Stoke University Hospital and North Staffordshire University, Stoke-on-Trent, ST4 6QG, UK.
University Hospitals of Morecambe Bay NHS Foundation Trust · GBWestern General Hospital · GBUniversity of Staffordshire · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewPheochromocytomas and paragangliomas (PPGLs) are uncommon catecholamine-producing neuroendocrine neoplasms that usually present with secondary hypertension. This review is to update the current knowledge about these neoplasms, the pathophysiology, genetic aspects and diagnostic and therapeutic algorithms based on scientific literature mostly within the past 3 years. RECENT

findingsEighty to eighty-five percent of PPGLs arise from the adrenal medulla (pheochromocytomas; PCCs) and the remainder from the autonomic neural ganglia (paragangliomas; PGLs). Catecholamine excess causes chronic or paroxysmal hypertension associated with sweating, headaches and palpitations, the presenting features of PPGLs, and increases the cardiovascular morbidity and mortality. Genetic testing should be considered in all cases as mutations are reported in 35-40% of cases; 10-15% of PCCs and 20-50% of PGLs can be malignant. Measurements of plasma-free metanephrines or 24-h urine-fractionated metanephrines help biochemical diagnosis with high sensitivity and specificity. Initial anatomical localization after biochemical confirmation is usually with computed tomography (CT) or magnetic resonance imaging (MRI).

Indexed as

Adrenal Gland NeoplasmsAlgorithmsGenetic TestingHumansHypertensionParagangliomaPheochromocytomaHypertensionParagangliomas (PGLs)Pheochromocytomas (PCCs)Plasma free metanephrinesUrine fractionated metanephrines

Identifiers

PMID29356966
OpenAlexW2786299201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.