ArticleAging2018
Predictors of gait speed and its change over three years in community-dwelling older people.
Article in Aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gait and falls in cerebral small vessel disease: a systematic review and meta-analysis.Age and ageing · 2023Pooled it
- Physical Function Impairment and Frailty in Middle-Aged People Living With Human Immunodeficiency Virus in the REPRIEVE Trial Ancillary Study PREPARE.The Journal of infectious diseases · 2020Trial
- Trial
- Assessment of Gait Disorders in Cerebral Small Vessel Disease: Advantages of Different Clinical Scales.Journal of clinical medicine · 2025Article
- Branched-Chain Amino Acids Combined with Exercise Improves Physical Function and Quality of Life in Older Adults: Results from a Pilot Randomized Controlled Trial.Dietetics (Basel, Switzerland) · 2025Article
- Relationship of Alzheimer's Disease and Related Dementias Plasma Biomarkers With Mobility in Cognitively Unimpaired Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Physical Resilience May Offset Mortality Risks Associated With Genetic Predisposition to Shorter Survival: A Population-based Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- What determines gait speed in community-living older adults? A relative weight analysis.European geriatric medicine · 2025Article
- Prediction of future aging-related slow gait and its determinants with deep learning and logistic regression.PloS one · 2025Article
- Cognition mediates the relationship between white matter hyperintensity and motor function in patients with cerebral small vessel disease: a cross-sectional study.Quantitative imaging in medicine and surgery · 2024Article
- Relationship between physical activity and cerebral white matter hyperintensity volumes in older adults with depressive symptoms and mild memory impairment: a cross-sectional study.Frontiers in aging neuroscience · 2024Article
- The Effect of Computerized Cognitive Training, with and without Exercise, on Cortical Volume and Thickness and Its Association with Gait Speed in Older Adults: A Secondary Analysis of a Randomized Controlled Trial.Journal of Alzheimer's disease reports · 2024Article
- Prevalence and Trends of Slow Gait Speed in the United States.Geriatrics (Basel, Switzerland) · 2023Article
- Changes in Physical Performance among Community-Dwelling Older Adults in Six Years.International journal of environmental research and public health · 2023Article
- Brain-Predicted Age Difference Moderates the Association Between Muscle Strength and Mobility.Frontiers in aging neuroscience · 2022Article
- Sarcopenia and Neuroscience: Learning to Communicate.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Grip strength from midlife as an indicator of later-life brain health and cognition: evidence from a British birth cohort.BMC geriatrics · 2021Article
- Factors associated with change in frailty scores and long-term outcomes in older adults with coronary artery disease.Journal of geriatric cardiology : JGC · 2021Article
- Putative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis.Journal of the American Geriatrics Society · 2020Observational
- A prospective study of focal brain atrophy, mobility and fitness.Journal of internal medicine · 2019Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
We aimed to assess whether and how changes in brain volume and increases in white matter hyperintensity (WMH) volume over three years predict gait speed and its change independently of demographics, vascular risk factors and physical status. We analyzed 443 individuals from the Lothian Birth Cohort 1936, at mean age 73 and 76 years. Gait speed at age 76 was predicted by age, grip strength and body mass index at mean age 73, three-year brain volume decrease and WMH volume increase, explaining 26.1% of variance. Decline in gait speed to age 76 was predicted by the same five variables explaining 40.9% of variance. In both analyses, grip strength and body mass index explained the most variance. A clinically significant decline in gait speed (≥ 0.1 m/s per year) occurred in 24.4%. These individuals had more structural brain changes. Brain volume and WMH changes were independent predictors of gait dysfunction and its three-year change, but the impact of malleable physical factors such as grip strength or body mass index was greater.
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Registered trials
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