Evidence map›Paper›PMID 29356607›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2018

Effects of Aerobic and Resistance Exercise on Metabolic Syndrome, Sarcopenic Obesity, and Circulating Biomarkers in Overweight or Obese Survivors of Breast Cancer: A Randomized Controlled Trial.

Christina M Dieli-Conwright, Kerry S Courneya, Wendy Demark-Wahnefried, Nathalie Sami, Kyuwan Lee, Thomas A Buchanan, Darcy V Spicer, Debu Tripathy, Leslie Bernstein, Joanne E Mortimer

Erratum issued Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07048847 (The Effect of Supervised Aerobic Exercise on Adipokine and Myokine Biomarkers in Patients With Cancer During Systemic Chemotherapy), which is not on this map. Cited by 212 papers, 30 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
212citing papers in PubMed, 30 pooled it
18.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07048847 completednot on this mapstarted 2022, after this paper: background citation

The Effect of Supervised Aerobic Exercise on Adipokine and Myokine Biomarkers in Patients With Cancer During Systemic Chemotherapy

TypeobservationalSponsorIzmir Bakircay UniversityRan2022 to 2023Enrolled32ConditionsBreast Cancer, Colon Cancer, Chemotherapy EffectArmsExercise
3 · Its place in the literature

Who cites it

212 citing papers in PubMed, 30 syntheses or guidelines pooled it, 346 citations in OpenAlex.

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  6. Hypertension and risk of cancer recurrence in adult survivors: A systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
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  14. Impact of exercise-based prehabilitation on cardiometabolic health in surgical patients with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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152 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Christina M Dieli-ConwrightChristina M. Dieli-Conwright, Nathalie Sami, Kyuwan Lee, Thomas A. Buchanan, and Darcy V. Spicer, University of Southern California, Los Angeles; Leslie Bernstein and Joanne E. Mortimer, City of Hope, Duarte, CA; Kerry S. Courneya, University of Alberta, Edmonton, Alberta, Canada; Wendy Demark-Wahnefried, University of Alabama at Birmingham, Birmingham, AL; and Debu Tripathy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Kerry S CourneyaChristina M. Dieli-Conwright, Nathalie Sami, Kyuwan Lee, Thomas A. Buchanan, and Darcy V. Spicer, University of Southern California, Los Angeles; Leslie Bernstein and Joanne E. Mortimer, City of Hope, Duarte, CA; Kerry S. Courneya, University of Alberta, Edmonton, Alberta, Canada; Wendy Demark-Wahnefried, University of Alabama at Birmingham, Birmingham, AL; and Debu Tripathy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Wendy Demark-WahnefriedChristina M. Dieli-Conwright, Nathalie Sami, Kyuwan Lee, Thomas A. Buchanan, and Darcy V. Spicer, University of Southern California, Los Angeles; Leslie Bernstein and Joanne E. Mortimer, City of Hope, Duarte, CA; Kerry S. Courneya, University of Alberta, Edmonton, Alberta, Canada; Wendy Demark-Wahnefried, University of Alabama at Birmingham, Birmingham, AL; and Debu Tripathy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Nathalie SamiChristina M. Dieli-Conwright, Nathalie Sami, Kyuwan Lee, Thomas A. Buchanan, and Darcy V. Spicer, University of Southern California, Los Angeles; Leslie Bernstein and Joanne E. Mortimer, City of Hope, Duarte, CA; Kerry S. Courneya, University of Alberta, Edmonton, Alberta, Canada; Wendy Demark-Wahnefried, University of Alabama at Birmingham, Birmingham, AL; and Debu Tripathy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Kyuwan LeeChristina M. Dieli-Conwright, Nathalie Sami, Kyuwan Lee, Thomas A. Buchanan, and Darcy V. Spicer, University of Southern California, Los Angeles; Leslie Bernstein and Joanne E. Mortimer, City of Hope, Duarte, CA; Kerry S. Courneya, University of Alberta, Edmonton, Alberta, Canada; Wendy Demark-Wahnefried, University of Alabama at Birmingham, Birmingham, AL; and Debu Tripathy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Thomas A BuchananChristina M. Dieli-Conwright, Nathalie Sami, Kyuwan Lee, Thomas A. Buchanan, and Darcy V. Spicer, University of Southern California, Los Angeles; Leslie Bernstein and Joanne E. Mortimer, City of Hope, Duarte, CA; Kerry S. Courneya, University of Alberta, Edmonton, Alberta, Canada; Wendy Demark-Wahnefried, University of Alabama at Birmingham, Birmingham, AL; and Debu Tripathy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Darcy V SpicerChristina M. Dieli-Conwright, Nathalie Sami, Kyuwan Lee, Thomas A. Buchanan, and Darcy V. Spicer, University of Southern California, Los Angeles; Leslie Bernstein and Joanne E. Mortimer, City of Hope, Duarte, CA; Kerry S. Courneya, University of Alberta, Edmonton, Alberta, Canada; Wendy Demark-Wahnefried, University of Alabama at Birmingham, Birmingham, AL; and Debu Tripathy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Debu TripathyChristina M. Dieli-Conwright, Nathalie Sami, Kyuwan Lee, Thomas A. Buchanan, and Darcy V. Spicer, University of Southern California, Los Angeles; Leslie Bernstein and Joanne E. Mortimer, City of Hope, Duarte, CA; Kerry S. Courneya, University of Alberta, Edmonton, Alberta, Canada; Wendy Demark-Wahnefried, University of Alabama at Birmingham, Birmingham, AL; and Debu Tripathy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Leslie BernsteinChristina M. Dieli-Conwright, Nathalie Sami, Kyuwan Lee, Thomas A. Buchanan, and Darcy V. Spicer, University of Southern California, Los Angeles; Leslie Bernstein and Joanne E. Mortimer, City of Hope, Duarte, CA; Kerry S. Courneya, University of Alberta, Edmonton, Alberta, Canada; Wendy Demark-Wahnefried, University of Alabama at Birmingham, Birmingham, AL; and Debu Tripathy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Joanne E MortimerChristina M. Dieli-Conwright, Nathalie Sami, Kyuwan Lee, Thomas A. Buchanan, and Darcy V. Spicer, University of Southern California, Los Angeles; Leslie Bernstein and Joanne E. Mortimer, City of Hope, Duarte, CA; Kerry S. Courneya, University of Alberta, Edmonton, Alberta, Canada; Wendy Demark-Wahnefried, University of Alabama at Birmingham, Birmingham, AL; and Debu Tripathy, The University of Texas MD Anderson Cancer Center, Houston, TX.

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2000 to 2026
$31.9M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Metabolic Syndrome and Breast Cancer: Effects of a Combined Exercise InterventionK07CA160718 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DIELI-CONWRIGHT, CHRISTINA · 2011 to 2015
$629k
NCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1 TR001855NCI NIH HHS K07 CA160718NIDDK NIH HHS P30 DK056336NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

Purpose Metabolic syndrome is associated with an increased risk of cardiovascular disease, type 2 diabetes, and breast cancer recurrence in survivors of breast cancer. This randomized controlled trial assessed the effects of a 16-week combined aerobic and resistance exercise intervention on metabolic syndrome, sarcopenic obesity, and serum biomarkers among ethnically diverse, sedentary, overweight, or obese survivors of breast cancer. Methods Eligible survivors of breast cancer (N = 100) were randomly assigned to exercise (n = 50) or usual care (n = 50). The exercise group participated in supervised moderate-to-vigorous-65% to 85% of heart rate maximum-aerobic and resistance exercise three times per week for 16 weeks. Metabolic syndrome z-score (primary outcome), sarcopenic obesity, and serum biomarkers were measured at baseline, postintervention (4 months), and 3-month follow-up (exercise only). Results Participants were age 53 ± 10.4 years, 46% were obese, and 74% were ethnic minorities. Adherence to the intervention was 95%, and postintervention assessments were available in 91% of participants. Postintervention metabolic syndrome z-score was significantly improved in exercise versus usual care (between-group difference, -4.4; 95% CI, -5.9 to -2.7; P < .001). Sarcopenic obesity (appendicular skeletal mass index, P = .001; body mass index, P = .001) and circulating biomarkers, including insulin ( P = .002), IGF-1 ( P = .001), leptin ( P = .001), and adiponectin ( P = .001), were significantly improved postintervention compared with usual care. At 3-month follow-up, all metabolic syndrome variables remained significantly improved compared with baseline in the exercise group ( P < .01). Conclusion Combined resistance and aerobic exercise effectively attenuated metabolic syndrome, sarcopenic obesity, and relevant biomarkers in an ethnically diverse sample of sedentary, overweight, or obese survivors of breast cancer. Our findings suggest a targeted exercise prescription for improving metabolic syndrome in survivors of breast cancer and support the incorporation of supervised clinical exercise programs into breast cancer treatment and survivorship care plans.

Indexed as

ExerciseBiomarkers, TumorBreast NeoplasmsFemaleHumansMetabolic SyndromeMiddle AgedNeoplasm Recurrence, LocalObesityOverweightResistance TrainingSarcopeniaTreatment OutcomeBiomarkers, Tumor

Identifiers

PMID29356607
PMCPMC5858524
OpenAlexW2784999756

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.