ArticlePlant biotechnology journal2018
Beyond pathways: genetic dissection of tocopherol content in maize kernels by combining linkage and association analyses.
Article in Plant biotechnology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 71 citations in OpenAlex.
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- Decades' progress and prospects on maize functional genomics and molecular breeding.Science China. Life sciences · 2025Review
- Vitamin E in Plants: Biosynthesis Pathways, Biofortification Strategies, and Regulatory Dynamics.International journal of molecular sciences · 2025Review
- Polymerization of beneficial plant height QTLs to develop superior lines which can achieving hybrid performance levels.Molecular breeding : new strategies in plant improvement · 2025Article
- Dynamic identification of candidate genes associated with higher tocopherol biosynthesis inFrontiers in plant science · 2025Article
- Beyond pathways: Accelerated flavonoids candidate identification and novel exploration of enzymatic properties using combined mapping populations of wheat.Plant biotechnology journal · 2024Article
- A Summary of Two Decades of QTL and Candidate Genes That Control Seed Tocopherol Contents in Maize (Genes · 2024Review
- Identification of Novel QTL for Mercury Accumulation in Maize Using an Enlarged SNP Panel.Genes · 2024Article
- Advancements and Prospects of Genome-Wide Association Studies (GWAS) in Maize.International journal of molecular sciences · 2024Review
- Genome-wide association study and genotypic variation for the major tocopherol content in rice grain.Frontiers in plant science · 2024Article
- Leveraging prior biological knowledge improves prediction of tocochromanols in maize grain.The plant genome · 2023Article
- Fine mapping and causal gene identification of a novel QTL for early flowering by QTL-seq, Target-seq and RNA-seq in spring oilseed rape.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Genetic basis of resistance to southern corn leaf blight in the maize multi-parent population and diversity panel.Plant biotechnology journal · 2023Article
- Genome-wide association analysis of kernel nutritional quality in two natural maize populations.Molecular breeding : new strategies in plant improvement · 2023Article
- Genetic dissection reveals the complex architecture of amino acid composition in soybean seeds.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Wheat and Rice beyond Phenolic Acids: Genetics, Identification Database, Antioxidant Properties, and Potential Health Effects.Plants (Basel, Switzerland) · 2022Review
- Association mapping across a multitude of traits collected in diverse environments in maize.GigaScience · 2022Article
- Role of Tocochromanols in Tolerance of Cereals to Biotic Stresses: Specific Focus on Pathogenic and Toxigenic Fungal Species.International journal of molecular sciences · 2022Review
- Combining GWAS and TWAS to identify candidate causal genes for tocochromanol levels in maize grain.Genetics · 2022Article
- Applications of Genomic Tools in Plant Breeding: Crop Biofortification.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although tocopherols play an important role in plants and animals, the genetic architecture of tocopherol content in maize kernels has remained largely unknown. In this study, linkage and association analyses were conducted to examine the genetic architecture of tocopherol content in maize kernels. Forty-one unique quantitative trait loci (QTLs) were identified by linkage mapping in six populations of recombinant inbred lines (RILs). In addition, 32 significant loci were detected via genome-wide association study (GWAS), 18 of which colocalized with the QTLs identified by linkage mapping. Fine mapping of a major QTL validated the accuracy of GWAS and QTL mapping results and suggested a role for nontocopherol pathway genes in the modulation of natural tocopherol variation. We provided genome-wide evidence that genes involved in fatty acid metabolism, chlorophyll metabolism and chloroplast function may affect natural variation in tocopherols. These findings were confirmed through mutant analysis of a particular gene from the fatty acid pathway. In addition, the favourable alleles for many of the significant SNPs/QTLs represented rare alleles in natural populations. Together, our results revealed many novel genes that are potentially involved in the variation of tocopherol content in maize kernels. Pyramiding of the favourable alleles of the newly elucidated genes and the well-known tocopherol pathway genes would greatly improve tocopherol content in maize.
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