ArticleAddiction (Abingdon, England)2018
Improving recruitment to pharmacological trials for illicit opioid use: findings from a qualitative focus group study.
Article in Addiction (Abingdon, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Comparative effectiveness of extended-release naltrexone versus buprenorphine-naloxone on treatment interruption: Comparing findings from a reanalysis of the X:BOT RCT and harmonized target trial emulation using population-based observational data.Addiction (Abingdon, England) · 2025Trial
- Do patients and the public understand and feel engaged and valued after reading outcome set study invitations? A UK qualitative study.BMJ open · 2026Article
- "The hardest part of what we're doing": research staff perspectives on engaging marginalized populations in substance use trials.Substance abuse treatment, prevention, and policy · 2025Article
- Feasibility of using real-world data to emulate substance use disorder clinical trials: a cross-sectional study.BMC medical research methodology · 2024Article
- S110-Opioid-free analgesia after outpatient general surgery: A qualitative study focused on the perspectives of patients and clinicians involved in a pilot trial.Surgical endoscopy · 2023Article
- Barriers, Facilitators and Experiences Linked to a Work-Related Case Management in Individuals with Substance Abuse Disorders.International journal of environmental research and public health · 2022Article
- Recruitment into a Clinical Trial of People Living with Uncontrolled HIV Infection Who Inject Drugs: a Site Case Report from the CTN 67 CHOICES Study.The journal of behavioral health services & research · 2022Article
- Potential Uses of Blockchain Technology for Outcomes Research on Opioids.JMIR medical informatics · 2021Article
- Experimental (Re)structuring: The Clinical Trial as Turning Point Among Medical Research Participants.Qualitative health research · 2021Article
- Mixed methods feasibility study for the surviving opioid overdose with naloxone education and resuscitation (SOONER) trial.Resuscitation plus · 2021Article
- Trust in research physicians as a key dimension of randomized controlled trial participation in clinical addictions research.Substance abuse · 2021Article
- Article
- Improving recruitment to pharmacological trials for illicit opioid use: findings from a qualitative focus group study.Addiction (Abingdon, England) · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo explore potential study participants' views on willingness to join clinical trials of pharmacological interventions for illicit opioid use to inform and improve future recruitment strategies.
designQualitative focus group study [six groups: oral methadone (two groups); buprenorphine tablets (two groups); injectable opioid agonist treatment (one group); and former opioid agonist treatment (one group)]. SETTINGS: Drug and alcohol services and a peer support recovery service (London, UK).
participantsForty people with experience of opioid agonist treatment for heroin dependence (26 males, 14 females; aged 33-66 years). MEASUREMENTS: Data collection was facilitated by a topic guide that explored willingness to enrol in clinical pharmacological trials. Groups were audio-recorded and transcribed. Transcribed data were analysed inductively via Iterative Categorization.
findingsParticipants' willingness to join pharmacological trials of medications for opioid dependence was affected by factors relating to study burden, study drug, study design, study population and study relationships. Participants worried that the trial drug might be worse than, or interfere with, their current treatment. They also misunderstood aspects of trial design despite the researchers' explanations.
conclusionsRecruitment of participants for clinical trials of pharmacological interventions for illicit opioid use could be improved if researchers became better at explaining clinical trials to potential participants, dispelling misconceptions about trials and increasing trust in the research process and research establishment. A checklist of issues to consider when designing pharmacological trials for illicit opioid use is proposed.
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