ReviewChemistry (Weinheim an der Bergstrasse, Germany)2018
Recent Advances in the Synthesis of Peptoid Macrocycles.
Review in Chemistry (Weinheim an der Bergstrasse, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 81 citations in OpenAlex.
- Late-Stage Functionalization of Peptides on the Solid Phase.Angewandte Chemie (International ed. in English) · 2026Review
- Antimicrobial Peptide-Peptoid Macrocycles from the Polymyxin B2 Chemical Space.Angewandte Chemie (International ed. in English) · 2025Article
- New insights into protein-protein interaction modulators in drug discovery and therapeutic advance.Signal transduction and targeted therapy · 2024Review
- Antimicrobial Peptide-Peptoid Hybrids with and without Membrane Disruption.ACS infectious diseases · 2023Article
- Antimicrobial and Adjuvant Potencies of Di-Antibiotics (Basel, Switzerland) · 2023Article
- Water-Soluble Chiral Cyclic Peptoids and Their Sodium and Gadolinium Complexes: Study of Conformational and Relaxometric Properties.The Journal of organic chemistry · 2023Article
- A Field Guide to Optimizing Peptoid Synthesis.ACS polymers Au · 2022Review
- Mapping the binding sites of challenging drug targets.Current opinion in structural biology · 2022Review
- Synthesis and Studies of Bulky Cycloalkyl α,β-Dehydroamino Acids that Enhance Proteolytic Stability.Organic letters · 2022Article
- Synthetic Receptors Based on Abiotic Cyclo(pseudo)peptides.Molecules (Basel, Switzerland) · 2022Review
- Macrocyclic DNA-encoded chemical libraries: a historical perspective.RSC chemical biology · 2022Review
- Chiral, sequence-definable foldamer-derived macrocycles.Chemical science · 2021Article
- Macrocyclic Tetramers-Structural Investigation of Peptide-Peptoid Hybrids.Molecules (Basel, Switzerland) · 2021Article
- Towards a streamlined synthesis of peptides containing α,β-dehydroamino acids.Tetrahedron letters · 2021Article
- Structural Diversity of Peptoids: Tube-Like Structures of Macrocycles.Molecules (Basel, Switzerland) · 2020Article
- Evaluating the Viability of Successive Ring-Expansions Based on Amino Acid and Hydroxyacid Side-Chain Insertion.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Self-Assembly of Supramolecular Architectures by the Effect of Amino Acid Residues of Quaternary Ammonium Pillar[5]arenes.International journal of molecular sciences · 2020Article
- Macrocycle synthesis strategy based on step-wise "adding and reacting" three components enables screening of large combinatorial libraries.Chemical science · 2020Article
- DNA origami protection and molecular interfacing through engineered sequence-defined peptoids.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Impact of Dehydroamino Acids on the Structure and Stability of Incipient 3The Journal of organic chemistry · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past two decades, developing medical applications for peptides has, and continues to be a highly active area of research. At present there are over 60 peptide-based drugs on the market and more than 140 in various stages of clinical trials. The interest in peptide-based therapeutics arises from their biocompatibility and their ability to form defined secondary and tertiary structures, resulting in a high selectivity for complex targets. However, there are significant challenges associated with the development of peptide-based therapeutics, namely peptides are readily metabolised in vivo. Peptoids are an emerging class of peptidomimetic and they offer an alternative to peptides. Peptoids are comprised of N-substituted glycines where side-chains are located on the nitrogen atom of the amide backbone rather than the α-carbon as is the case in peptides. This change in structure confers a high degree of resistance to proteolytic degradation but the absence of any backbone hydrogen bonding means that peptoids exhibit a high degree of conformational flexibility. Cyclisation has been explored as one possible route to rigidify peptoid structures, making them more selective, and, therefore more desirable as potential therapeutics. This review outlines the various strategies that have been developed over the last decade to access new types of macrocyclic peptoids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.