Evidence map›Paper›PMID 29356026›Full record

ArticleLasers in surgery and medicine2018

Light-emitting diodes in dermatology: A systematic review of randomized controlled trials.

Jared Jagdeo, Evan Austin, Andrew Mamalis, Christopher Wong, Derek Ho, Daniel M Siegel

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lasers in surgery and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07311889 (Assessment of Patient Satisfaction and Healing Outcomes With the ELIXIR MD™ Device in the Perioperative Period of Plastic Surgery), which is not on this map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07311889 enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Assessment of Patient Satisfaction and Healing Outcomes With the ELIXIR MD™ Device in the Perioperative Period of Plastic Surgery

TypeobservationalSponsorElixir MD IncRan2026 to 2027Enrolled300ConditionsPostoperative Pain, Postoperative Edema, Postoperative Ecchymosis, Surgical Wound HealingArmsPerioperative photobiomodulation light therapy
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  9. Comment on home LED masks and skin of colour: the pigmentary blind spot written by Professor Fasal R. Ali in reference to Baeza-Moyano et al., Photochem Photobiol Sci 2026;25:1179-1188.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  10. Spectral emission variability in commercial led masks for cosmetic use.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jared JagdeoDepartment of Dermatology, University of California at Davis, Sacramento, California.
Evan AustinDepartment of Dermatology, University of California at Davis, Sacramento, California.
Andrew MamalisDepartment of Dermatology, Downstate Medical Center, State University of New York, Brooklyn, New York.
Christopher WongDermatology Service, Sacramento VA Medical Center, Mather, California.
Derek HoDepartment of Dermatology, University of California at Davis, Sacramento, California.
Daniel M SiegelDepartment of Dermatology, Downstate Medical Center, State University of New York, Brooklyn, New York.

Funding

Light Emitting Diod-Red Light Phototherapy for Skin FibrosisK23GM117309 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JAGDEO, JARED R · 2016 to 2019
$777k
NIGMS NIH HHS K23 GM117309
6 · The paper itself

Abstract

objectiveIn dermatology, patient and physician adoption of light-emitting diode (LED) medical technology continues to grow as research indicates that LEDs may be used to treat skin conditions. The goal of this systematic review is to critically analyze published randomized controlled trials (RCTs) and provide evidence-based recommendations on the therapeutic uses of LEDs in dermatology based on published efficacy and safety data.

methodsA systematic review of the published literature on the use of LED treatments for skin conditions was performed on September 13th 2017.

resultsThirty-one original RCTs were suitable for review.

conclusionsLEDs represent an emerging modality to alter skin biology and change the paradigm of managing skin conditions. Acne vulgaris, herpes simplex and zoster, and acute wound healing received grade of recommendation B. Other skin conditions received grade of recommendation C or D. Limitations of some studies include small patient sample sizes (n < 20), absent blinding, no sham placebo, and varied treatment parameters. Due to few incidences of adverse events, affordability, and encouraging clinical results, we recommend that physicians use LEDs in clinical practice and researchers continue to explore the use of LEDs to treat skin conditions. Lasers Surg. Med. 9999:1-16, 2018. © 2018 The Authors. Lasers in Surgery and Medicine Published by Wiley Periodicals, Inc.

Indexed as

light-emitting diodephotobiomodulationphototherapyskin therapy

Identifiers

PMID29356026
PMCPMC6099480

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.