Evidence map›Paper›PMID 29355960›Full record

ArticleInternational journal of cancer2018

Occupational radiation exposure and thyroid cancer incidence in a cohort of U.S. radiologic technologists, 1983-2013.

Cari M Kitahara, Dale L Preston, Gila Neta, Mark P Little, Michele M Doody, Steven L Simon, Alice J Sigurdson, Bruce H Alexander, Martha S Linet

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00410475 (Cancer Risk in X-Ray Technologists), which is not on this map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00410475 completednot on this map

Cancer Risk in X-Ray Technologists

TypeobservationalSponsorNational Cancer Institute (NCI)Ran1997 to 2020Enrolled146,022ConditionsRadiation-Induced Neoplasms, Breast+Neoplasm+Radiation+Etiology, Thyroid+Neoplasm+Radiation+Etiology
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Cari M KitaharaDivision of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-6416-4432
Dale L PrestonHirosoft International, Eureka, CA.ORCID 0000-0002-0641-2925
Gila NetaDivision of Cancer Control and Population Sciences, Implementation Science, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Mark P LittleDivision of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Michele M DoodyDivision of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Steven L SimonDivision of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Alice J SigurdsonDivision of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Bruce H AlexanderDivision of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, MN.
Martha S LinetDivision of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
National Institutes of Health · USISCO International (United States) · USUniversity of Minnesota · US

Funding

Studies of Populations Exposed to Occupational Sources of RadiationZIACP010133 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI KITAHARA, CARI · 2009 to 2025
$34.2M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA CP010133NULL Z99 CA999999NULL ZIA CP010133-21
6 · The paper itself

Abstract

Although childhood exposure to ionizing radiation is a well-established risk factor for thyroid cancer, the risk associated with adulthood exposure remains unclear. We prospectively examined the association between cumulative, low-to-moderate dose occupational radiation exposure to the thyroid and thyroid cancer incidence in the U.S. Radiologic Technologists cohort. The study included 89,897 members who completed at least two of four mailed questionnaires and were cancer-free at the time of the first questionnaire. Cumulative occupational thyroid radiation dose (mean = 57 mGy, range = 0-1,600 mGy) was estimated based on self-reported work histories, historical data and, during the years 1960-1997, 783,000 individual film badge measurements. During follow-up, we identified 476 thyroid cancer cases. We used Poisson regression to estimate excess relative risk of thyroid cancer per 100 milliGray (ERR/100 mGy) absorbed dose to the thyroid gland. After adjusting for attained age, sex, birth year, body mass index and pack-years smoked, we found no association between thyroid dose and thyroid cancer risk (ERR/100 mGy = -0.05, 95% CI <-0.10, 0.34). In this large cohort study of radiologic technologists, protracted, low-to-moderate dose ionizing radiation exposure to the thyroid gland in adulthood was not associated with an increased risk of thyroid cancer.

Indexed as

Technology, RadiologicAdenocarcinoma, FollicularAllied Health PersonnelCarcinoma, PapillaryFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasms, Radiation-InducedOccupational ExposurePrognosisProspective StudiesRadiation DosageRadiation ExposureRadiation, Ionizingcohort studyionizing radiationoccupational exposureradiologic technologiststhyroid cancer

Identifiers

PMID29355960
PMCPMC6054904
OpenAlexW2791445785

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.