ArticleDevelopmental psychobiology2018
Oxytocin receptor gene polymorphisms (rs53576) and early paternal care sensitize males to distressing female vocalizations.
Article in Developmental psychobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Pleiotropic effects of oxytocin receptor polymorphisms: influencing striatocortical connectivity in bipolar disorder.International journal of bipolar disorders · 2025Article
- Repetitive transcranial magnetic stimulation alleviates neuropathic pain via microglial polarization by modulating the METTL3/NMDAR2B/NLRP3 pathway.Frontiers in immunology · 2025Article
- The Predisposition for Type 2 Diabetes Mellitus and Metabolic Syndrome.Balkan journal of medical genetics : BJMG · 2023Article
- Article
- Serotonin Transporter Gene Polymorphisms and Maternal Overprotection Regulate Adult Social Expectations on Close Relationships.Brain sciences · 2021Article
- Recalled Parental Bonding Interacts with Oxytocin Receptor Gene Polymorphism in Modulating Anxiety and Avoidance in Adult Relationships.Brain sciences · 2021Article
- Influence of Two Single-Nucleotide Polymorphisms of the Oxytocin Receptor Gene (OXTR) on Empathy: the Mediation Role of a Primary Emotion, CARE.Journal of molecular neuroscience : MN · 2021Article
- Oxytocin Receptor Gene Polymorphisms and Early Parental Bonding Interact in Shaping Instagram Social Behavior.International journal of environmental research and public health · 2020Article
- Parents' Past Bonding Experience with Their Parents Interacts with Current Parenting Stress to Influence the Quality of Interaction with Their Child.Behavioral sciences (Basel, Switzerland) · 2020Article
- Oxytocin receptor gene and parental bonding modulate prefrontal responses to cries: a NIRS Study.Scientific reports · 2020Article
- Gene × Environment Interaction in Developmental Disorders: Where Do We Stand and What's Next?Frontiers in psychology · 2018Article
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Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
Abstract
The oxytocinergic system is highly involved in social bonding and early caregiver-infant interactions. Here, we hypothesize that oxytocin receptor (OXTR) gene genotype and parental bonding history interact in influencing social development. To address this question, we assessed adult males' arousal (heart rate changes) in response to different distress vocalizations (human female, human infant and bonobo). Region rs53576 of the OXTR gene was genotyped from buccal mucosa cell samples, and a self-report Parental Bonding Instrument was used (which provide information about parental care or parental overprotection). A significant gene-environment interaction between OXTR genotype and parenting style was found to influence participants' social responsivity to female cry vocalizations. Specifically, a history of appropriate paternal care in participants accentuated the heightened social sensitivity determined by G/G homozygosity, while higher versus lower paternal overprotection lead to distinct levels of physiological arousal particularly in A carriers individuals. These results add to our understanding of the dynamic interplay between genetic susceptibility and early environmental experience in shaping the development of appropriate social sensitivity in males.
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