ArticleCancer2018
Depressive symptoms predict head and neck cancer survival: Examining plausible behavioral and biological pathways.
Article in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Psychological Factors Related to Treatment Outcomes in Head and Neck Cancer.Advances in therapy · 2024Pooled it
- Major Depression and Survival in People With Cancer.Psychosomatic medicine · 2021Pooled it
- Multidisciplinary Team Support for Patients With Head and Neck Cancer Receiving Radiotherapy: A Randomized Clinical Trial.JAMA network open · 2025Trial
- De-Novo Depression, Prophylactic Antidepressant, and Survival in Patients With Head and Neck Cancer.The Laryngoscope · 2023Trial
- [Prevention in oncological follow-up].HNO · 2026Review
- Out-of-Pocket Costs and Antidepressant Adherence in Head and Neck Cancer Survivors.Psycho-oncology · 2026Article
- Mediators of the association between psychological distress and mortality in people diagnosed with cancer.Nature communications · 2025Article
- Low resilience in patients with cancer as a factor influencing anxiety, depression, and quality-of-life.World journal of psychiatry · 2025Article
- Demographic Disparities in Diagnosis and Treatment of Anxiety and Depressive Disorders in Head and Neck Cancer Survivors.Head & neck · 2025Article
- Cancer neuroscience in head and neck: interactions, modulation, and therapeutic strategies.Molecular cancer · 2025Review
- Patient-Reported Distress in Individuals With Head and Neck Cancer.JAMA otolaryngology-- head & neck surgery · 2025Article
- Health-related quality of life assessment in head and neck cancer: A systematic review of phase II and III clinical trials.Heliyon · 2024Article
- The role of prehabilitation in HNSCC patients treated with chemoradiotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Review
- Anxiety symptoms predict head and neck cancer survival: Exploring mediation by systemic inflammation and tumor response to treatment.Psycho-oncology · 2024Article
- Factors associated with oral hygiene compliance in patients treated with radiation therapy for head and neck cancer.Journal of the American Dental Association (1939) · 2024Observational
- Oral Health in Patients with History of Head and Neck Cancer: Complexity and Benefits of a Targeted Oral Healthcare Pathway.Current oncology reports · 2024Review
- Early Improved Functional Outcomes in Head and Neck Cancer Patients with Primary Tumor Detection.The Laryngoscope · 2024Article
- Evening cortisol levels are prognostic for progression-free survival in a prospective pilot study of head and neck cancer patients.Frontiers in oncology · 2024Article
- The role of illness-related cognition in the relationships between resilience and depression/anxiety in nasopharyngeal cancer patients.Cancer medicine · 2023Article
- Underserved head-and-neck and lung cancer patient characteristics are associated with caregiver participation in a clinical trial.Contemporary clinical trials communications · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundHead and neck cancers are associated with high rates of depression, which may increase the risk for poorer immediate and long-term outcomes. Here it was hypothesized that greater depressive symptoms would predict earlier mortality, and behavioral (treatment interruption) and biological (treatment response) mediators were examined.
methodsPatients (n = 134) reported depressive symptomatology at treatment planning. Clinical data were reviewed at the 2-year follow-up.
resultsGreater depressive symptoms were associated with significantly shorter survival (hazard ratio, 0.868; 95% confidence interval [CI], 0.819-0.921; P < .001), higher rates of chemoradiation interruption (odds ratio, 0.865; 95% CI, 0.774-0.966; P = .010), and poorer treatment response (odds ratio, 0.879; 95% CI, 0.803-0.963; P = .005). The poorer treatment response partially explained the depression-survival relation. Other known prognostic indicators did not challenge these results.
conclusionsDepressive symptoms at the time of treatment planning predict overall 2-year mortality. Effects are partly influenced by the treatment response. Depression screening and intervention may be beneficial. Future studies should examine parallel biological pathways linking depression to cancer survival, including endocrine disruption and inflammation. Cancer 2018;124:1053-60. © 2018 American Cancer Society.
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