Evidence map›Paper›PMID 29355769›Full record

ArticleNeuroImage2018

Mapping population-based structural connectomes.

Zhengwu Zhang, Maxime Descoteaux, Jingwen Zhang, Gabriel Girard, Maxime Chamberland, David Dunson, Anuj Srivastava, Hongtu Zhu

Abstract read
In one paragraph

Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhengwu ZhangDepartment of Biostatistics and Computational Biology, Rochester, NY, USA; Statistical and Applied Mathematical Sciences Institute, Durham, NC, USA.
Maxime DescoteauxSherbrooke Connectivity Imaging Lab (SCIL), Computer Science Department, Université de Sherbrooke, Sherbrooke, QC, Canada.
Jingwen ZhangDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Gabriel GirardSherbrooke Connectivity Imaging Lab (SCIL), Computer Science Department, Université de Sherbrooke, Sherbrooke, QC, Canada.
Maxime ChamberlandSherbrooke Connectivity Imaging Lab (SCIL), Computer Science Department, Université de Sherbrooke, Sherbrooke, QC, Canada.
David DunsonDepartment of Statistical Science, Duke University, Durham, NC, USA.
Anuj SrivastavaDepartment of Statistics, Florida State University, Tallahassee, FL, USA.
Hongtu ZhuDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: hzhu5@mdanderson.org.

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Statistical Analysis of Biomedical Imaging Data in Curved SpaceR01MH086633 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI IBRAHIM, JOSEPH G · 2010 to 2018
$2.9M
Genome-wide Identification of Variants Affecting Early Human Brain DevelopmentR01MH092335 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KNICKMEYER, REBECCA · 2011 to 2015
$2.5M
NIMH NIH HHS R01 MH086633NIMH NIH HHS R01 MH092335NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

Advances in understanding the structural connectomes of human brain require improved approaches for the construction, comparison and integration of high-dimensional whole-brain tractography data from a large number of individuals. This article develops a population-based structural connectome (PSC) mapping framework to address these challenges. PSC simultaneously characterizes a large number of white matter bundles within and across different subjects by registering different subjects' brains based on coarse cortical parcellations, compressing the bundles of each connection, and extracting novel connection weights. A robust tractography algorithm and streamline post-processing techniques, including dilation of gray matter regions, streamline cutting, and outlier streamline removal are applied to improve the robustness of the extracted structural connectomes. The developed PSC framework can be used to reproducibly extract binary networks, weighted networks and streamline-based brain connectomes. We apply the PSC to Human Connectome Project data to illustrate its application in characterizing normal variations and heritability of structural connectomes in healthy subjects.

Indexed as

AlgorithmsBrainConnectomeHumansImage Processing, Computer-AssistedBrain connectomeDiffusion MRI imagingFunctional principal component analysisHuman connectome projectPopulation-based structural connectomeStreamline variation decomposition

Identifiers

PMID29355769
PMCPMC5910206

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.