Evidence map›Paper›PMID 29355767›Full record

ReviewNeuroImage2018

Co-activation patterns in resting-state fMRI signals.

Xiao Liu, Nanyin Zhang, Catie Chang, Jeff H Duyn

Registry-linked trialAbstract readReview
In one paragraph

Review in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05993351 (Correlating Advanced MRI Techniques With Neuropsychological Analysis and Immunosensing Assays for Assessment of Sport-related Mild Traumatic Brain Injuries), which is not on this map. Cited by 136 papers.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05993351 recruitingnot on this mapstarted 2023, after this paper: background citation

Correlating Advanced MRI Techniques With Neuropsychological Analysis and Immunosensing Assays for Assessment of Sport-related Mild Traumatic Brain Injuries (mTBI)

TypeobservationalSponsorSt. Joseph's Healthcare HamiltonRan2023 to 2026Enrolled100ConditionsConcussion, BrainArmsMagnetic resonance imaging (MRI), Urine and saliva samples, Questionnaires
3 · Its place in the literature

Who cites it

136 citing papers in PubMed.

  1. From rest to focus: pharmacological modulation of the relationship between resting state dorsal attention network dynamics and task-based brain activation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Trial
  2. Trial
  3. Polarisation of brain dynamics in mania and depression.Dialogues in clinical neuroscience · 2026
    Article
  4. Imaging biomarkers in functional neurological disorders.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  5. Sharp and smooth state transitions during resting state brain dynamics.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Article
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  10. Predicting individual incubation of opioid craving by whole-brain functional connectivity.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Executive Dysfunction and Depression Risk in Adolescence: Functional-MRI Analysis of Transient Network States During a Working Memory Task.Clinical psychological science : a journal of the Association for Psychological Science · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
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  19. Article
  20. Article

76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiao LiuDepartment of Biomedical Engineering, The Pennsylvania State University, PA, USA; Institute for CyberScience, The Pennsylvania State University, PA, USA. Electronic address: xxl213@engr.psu.edu.
Nanyin ZhangDepartment of Biomedical Engineering, The Pennsylvania State University, PA, USA; The Huck Institutes of Life Sciences, The Pennsylvania State University, PA, USA.
Catie ChangAdvanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Jeff H DuynAdvanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

Funding

Magnetic Resonance Imaging of Human Brain Anatomy and FunctionZIANS003027 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI DUYN, JEFF · 2009 to 2025
$31.2M
Neural Basis of Resting-State Functional ConnectivityR00NS092996 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI LIU, XIAO · 2017 to 2019
$732k
Tracking brain arousal fluctuations for fMRI Big Data discoveryK22ES028048 · NIEHS · VANDERBILT UNIVERSITY · PI CHANG, CATHERINE ELIZABETH · 2018 to 2020
$606k
NIEHS NIH HHS K22 ES028048NINDS NIH HHS R00 NS092996
6 · The paper itself

Abstract

The brain is a complex system that integrates and processes information across multiple time scales by dynamically coordinating activities over brain regions and circuits. Correlations in resting-state functional magnetic resonance imaging (rsfMRI) signals have been widely used to infer functional connectivity of the brain, providing a metric of functional associations that reflects a temporal average over an entire scan (typically several minutes or longer). Not until recently was the study of dynamic brain interactions at much shorter time scales (seconds to minutes) considered for inference of functional connectivity. One method proposed for this objective seeks to identify and extract recurring co-activation patterns (CAPs) that represent instantaneous brain configurations at single time points. Here, we review the development and recent advancement of CAP methodology and other closely related approaches, as well as their applications and associated findings. We also discuss the potential neural origins and behavioral relevance of CAPs, along with methodological issues and future research directions in the analysis of fMRI co-activation patterns.

Indexed as

BrainBrain MappingHumansMagnetic Resonance ImagingNerve NetRestCo-activation brain patternsDynamic brain connectivityResting-state fMRI

Identifiers

PMID29355767
PMCPMC6082734

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.