ArticleBehavioural brain research2018
Anxiety-like behavior and neuropeptide receptor expression in male and female prairie voles: The effects of stress and social buffering.
Article in Behavioural brain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Social touch-like tactile stimulation alleviates stress-induced anxiety-like behavior by enhancing the oxytocin level in the prefrontal cortex.Neurobiology of stress · 2026Article
- Paternal predatory risk alters parental behavior and offspring phenotypes in biparental Brandt's voles.Current zoology · 2025Article
- A review of the effects of different types of social behaviors on the recruitment of neuropeptides and neurotransmitters in the nucleus accumbens.Frontiers in neuroendocrinology · 2025Review
- Pair bond quality influences social conditioned place preference expression, passive coping behavior, and central oxytocin receptor expression following partner loss in male prairie voles.Social neuroscience · 2024Article
- Attachment across the lifespan: Examining the intersection of pair bonding neurobiology and healthy aging.Neuroscience and biobehavioral reviews · 2023Review
- Behavioral, neurochemical, and neuroimmune changes associated with social buffering and stress contagion.Neurobiology of stress · 2022Article
- Behavioral trajectories of aging prairie voles (Microtus ochrogaster): Adapting behavior to social context wanes with advanced age.PloS one · 2022Article
- Neurobiology of Loneliness, Isolation, and Loss: Integrating Human and Animal Perspectives.Frontiers in behavioral neuroscience · 2022Review
- Convergent neuroendocrine mechanisms of social buffering and stress contagion.Hormones and behavior · 2021Review
- Role of Medial Prefrontal Cortical Neurons and Oxytocin Modulation in the Establishment of Social Buffering.Experimental neurobiology · 2021Article
- Sex-Dependent Effects of Chronic Social Defeat on Emotional and Social Behaviors, and Parameters of Oxytocin and Vasopressin Systems in Mandarin Voles (Frontiers in neuroscience · 2021Article
- Enhancement of Oxytocin in the Medial Prefrontal Cortex Reverses Behavioral Deficits Induced by Repeated Ketamine Administration in Mice.Frontiers in neuroscience · 2021Article
- Reduced Consolation Behaviors in Physically Stressed Mandarin Voles: Involvement of Oxytocin, Dopamine D2, and Serotonin 1A Receptors Within the Anterior Cingulate Cortex.The international journal of neuropsychopharmacology · 2020Article
- Oxytocin receptor antagonist reverses the blunting effect of pair bonding on fear learning in monogamous prairie voles.Hormones and behavior · 2020Article
- The mere physical presence of another person reduces human autonomic responses to aversive sounds.Proceedings. Biological sciences · 2020Article
- Dopamine D1-like receptors regulate agonistic components of pair bond maintenance behaviors in male titi monkeys (Callicebus cupreus).Psychoneuroendocrinology · 2019Article
- Role of oxytocin in the control of stress and food intake.Journal of neuroendocrinology · 2019Review
- Consequences of prenatal exposure to valproic acid in the socially monogamous prairie voles.Scientific reports · 2019Article
- Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Oxytocin and Vasopressin, and the GABA Developmental Shift During Labor and Birth: Friends or Foes?Frontiers in cellular neuroscience · 2018Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
Strong social support can negate negative health outcomes - an effect defined as 'social buffering'. In the present study, using the socially monogamous prairie vole (Microtus ochrogaster), we examined whether the presence of a bonded partner during a stressful event can reduce stress responses. Adult, pair-bonded female and male voles were assigned into experimental groups that were either handled (Control), experienced a 1-h immobilization (IMO) stress alone (IMO-Alone), or experienced IMO with their partner (IMO-Partner). Thereafter, subjects were tested for anxiety-like behavior, and brain sections were subsequently processed for oxytocin receptor (OTR) and vasopressin V1a-type receptor (V1aR) binding. Our data indicate that while IMO stress significantly decreased the time that subjects spent in the open arms of an elevated plus maze, partner's presence prevented this behavioral change - this social buffering on anxiety-like behavior was the same for both male and female subjects. Further, IMO stress decreased OTR binding in the nucleus accumbens (NAcc), but a partner's presence dampened this effect. No effects were found in V1aR binding. These data suggest that the neuropeptide- and brain region-specific OTR alterations in the NAcc may be involved in both the mediation and social buffering of stress responses. Some sex differences in the OTR and V1aR binding were also found in selected brain regions, offering new insights into the sexually dimorphic roles of the two neuropeptides. Overall, our results suggest a potential preventative approach in which the presence of social interactions during a stressor may buffer typical negative outcomes.
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