ReviewAdvances in dental research2018
Therapeutic Strategies Targeting Cariogenic Biofilm Microenvironment.
Review in Advances in dental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus mutans: a systematic review of in vitro studies.BMC oral health · 2024Pooled it
- Pooled it
- Geraniol attenuates Streptococcus mutans biofilm and virulence as an anti-caries agent.Archives of microbiology · 2026Article
- Modulating Oral Microbiota to Prevent Dental Caries: A Microbial Ecology Approach.Dentistry journal · 2026Review
- Computational examination of magainin-I-KL mediated disruption of E. coli biofilms via CsgA amyloid interference.Archives of microbiology · 2026Article
- pH-responsive nanozymes: multifunctional platforms for biomedical catalysis toward clinical translation.Frontiers in bioengineering and biotechnology · 2026Review
- Curcumin Internalization in Streptococcus mutans Biofilms: A Confocal Microscopy Analysis.Journal of biophotonics · 2025Article
- Effectiveness of biofilm-targeted therapy in managing and preventing dental caries: protocol for a systematic review and meta-analysis.Systematic reviews · 2025Article
- Anti-cariogenic activity of mutanocyclin, a secondary metabolite ofMicrobiology spectrum · 2025Article
- Saliva-acquired pellicle inspired multifunctional gargle with wet adhesion, photodynamic antimicrobial, and In situ remineralization properties for dental caries prevention.Bioactive materials · 2025Article
- Antimicrobial, remineralization, and infiltration: advanced strategies for interrupting dental caries.Medical review (2021) · 2025Review
- Natural compounds: new therapeutic approach for inhibition ofFrontiers in pharmacology · 2025Review
- Review
- Biochemical properties of a Flavobacterium johnsoniae dextranase and its biotechnological potential for Streptococcus mutans biofilm degradation.World journal of microbiology & biotechnology · 2024Article
- Effect of adding arginine at different concentrations to experimental orthodontic resins: an in vitro study.Brazilian oral research · 2024Article
- Mechanism of Action ofAntibiotics (Basel, Switzerland) · 2023Article
- Anticariogenic Activity of Celastrol and Its Enhancement of Streptococcal Antagonism in Multispecies Biofilm.Antibiotics (Basel, Switzerland) · 2023Article
- Targeting cariogenic pathogens and promoting competitiveness of commensal bacteria with a novel pH-responsive antimicrobial peptide.Journal of oral microbiology · 2023Article
- pH-activated antibiofilm strategies for controlling dental caries.Frontiers in cellular and infection microbiology · 2023Review
- Farnesol delivery via polymeric nanoparticle carriers inhibits cariogenic cross-kingdom biofilms and prevents enamel demineralization.Molecular oral microbiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Cariogenic biofilms are highly structured microbial communities embedded in an extracellular matrix, a multifunctional scaffold that is essential for the existence of the biofilm lifestyle and full expression of virulence. The extracellular matrix provides the physical and biological properties that enhance biofilm adhesion and cohesion, as well as create a diffusion-modulating milieu, protecting the resident microbes and facilitating the formation of localized acidic pH niches. These biochemical properties pose significant challenges for the development of effective antibiofilm therapeutics to control dental caries. Conventional approaches focusing solely on antimicrobial activity or enhancing remineralization may not achieve maximal efficacy within the complex biofilm microenvironment. Recent approaches disrupting the biofilm microbial community and the microenvironment have emerged, including specific targeting of cariogenic pathogens, modulation of biofilm pH, and synergistic combination of bacterial killing and matrix degradation. Furthermore, new "smart" nanotechnologies that trigger drug release or activation in response to acidic pH are being developed that could enhance the efficacy of current and prospective chemical modalities. Therapeutic strategies that can locally disrupt the pathogenic niche by targeting the biofilm structure and its microenvironment to eliminate the embedded microorganism and facilitate the action of remineralizing agents may lead to enhanced and precise anticaries approaches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.