ReviewNature reviews. Nephrology2018
Reproductive health and pregnancy in women with chronic kidney disease.
Review in Nature reviews. Nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Systematic review of pregnancy and renal outcomes for women with chronic kidney disease receiving assisted reproductive therapy.Journal of nephrology · 2022Pooled it
- Clinical practice guideline on pregnancy and renal disease.BMC nephrology · 2019Guideline
- Prolonged Ovarian Hyperstimulation Syndrome in a Patient With Advanced Kidney Disease.Kidney medicine · 2026Article
- Pregnancy Outcomes and Associated Complications in Patients Undergoing Hemodialysis and Their Neonates: A Nationwide Study in South Korea (2014-2022).Journal of clinical medicine · 2026Article
- Placental DNA methylation dysregulation underlies fetal growth restriction associated with maternal pre-pregnancy underweight.BMC pregnancy and childbirth · 2026Article
- Nephrology Survey on Reproductive Health and Kidney Disease.Kidney international reports · 2026Article
- Reproductive Health Knowledge and Educational Priorities in Chronic Kidney Disease: A Cross-Sectional Survey of People With CKD.Kidney medicine · 2026Article
- Unravelling sex-specific differences in autosomal dominant polycystic kidney disease: a multiorgan perspective.Clinical kidney journal · 2026Review
- Impact of assisted reproductive therapy on kidney and pregnancy outcomes in women with early-stage chronic kidney disease: a longitudinal analysis.BMC pregnancy and childbirth · 2025Article
- Recommendations for management of pregnancy complicated by Caroli disease: A case report and literature review.iLIVER · 2025Article
- Kidney and Pregnancy: A Comprehensive Review.Clinics and practice · 2025Review
- Personalized dialysis: use of ultrasonography as a guide for ultrafiltration in hemodialysis during pregnancy. Case reportRevista colombiana de obstetricia y ginecologia · 2025Article
- Impact of CKD on Female Reproductive Hormones.Kidney international reports · 2025Article
- Safety of Drugs in Breastfeeding Women With CKD.Kidney international reports · 2025Article
- Family Planning in Patients With ADPKD-Results From the DIPAK Consortium.Kidney international reports · 2025Article
- Pregnancy in chronic hemodialysis in a resource-limited country: case report and literature review.BMC nephrology · 2025Review
- Severe kidney dysfunction after assisted reproductive technology: a case series suggesting the need for higher awareness of risks.Journal of nephrology · 2025Article
- Pre-pregnancy care in general practice in England: cross-sectional observational study using administrative routine health data.BMC public health · 2025Observational
- Kidney disease and reproductive health.Nature reviews. Nephrology · 2025Review
- Defining normal serum creatinine in pregnancy-results from the AKID UK prospective cohort study.Clinical kidney journal · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Chronic kidney disease (CKD) is associated with reduced fertility and an increased risk of adverse pregnancy outcomes. Rates of pre-eclampsia, fetal growth restriction and preterm delivery increase incrementally with the severity of CKD and proteinuria. Pre-pregnancy counselling can facilitate informed decision-making. Safe and effective contraception is required for women who wish to delay or avoid pregnancy. Pregnancy planning for women who wish to conceive involves appropriate substitution of known teratogens - including mycophenolate mofetil, angiotensin blockers and cyclophosphamide - and can aid optimization of disease control. However, pregnancy, which can occur in women with any stage of CKD, can exacerbate comorbidities such as anaemia, vitamin D deficiency and hypertension. Increased haemodialysis provision is associated with improved pregnancy outcomes for women on dialysis. Diagnosis of pre-eclampsia in women with CKD is complicated in patients with pre-existing hypertension and proteinuria but can be improved by the use of vasoactive biomarkers as well as placental and fetal Doppler ultrasound. Pregnancy data for newer drugs used in CKD are limited as pregnancy and CKD are common exclusion criteria for drug and intervention trials. Although prospective data may be available for older drugs, the use of most drugs in pregnancy is based on retrospective data and expert consensus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.