Evidence map›Paper›PMID 29355077›Full record

ArticleFly2018

The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity.

Annabelle Suisse, Miklós Békés, Tony T Huang, Jessica E Treisman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fly, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Annabelle Suissea Helen L. and Martin S. Kimmel Center at the Skirball Institute for Biomolecular Medicine and Department of Cell Biology , NYU School of Medicine , 540 First Avenue, New York , NY , USA.ORCID 0000-0001-8542-7545
Miklós Békésb Department of Biochemistry and Molecular Pharmacology , NYU School of Medicine , 540 First Avenue, New York , NY , USA.
Tony T Huangb Department of Biochemistry and Molecular Pharmacology , NYU School of Medicine , 540 First Avenue, New York , NY , USA.ORCID 0000-0001-9291-5002
Jessica E Treismana Helen L. and Martin S. Kimmel Center at the Skirball Institute for Biomolecular Medicine and Department of Cell Biology , NYU School of Medicine , 540 First Avenue, New York , NY , USA.ORCID 0000-0002-7453-107X
New York University · US

Funding

Pattern formation in the eye discR01EY013777 · NEI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TREISMAN, JESSICA E · 2002 to 2017
$5.8M
Mechanisms of reversible DUB oxidation in genome stability pathways - RevisionR01ES025166 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HUANG, TONY TUNG · 2015 to 2020
$2.3M
NEI NIH HHS R01 EY013777NIEHS NIH HHS R01 ES025166
6 · The paper itself

Abstract

The COP9 signalosome inhibits the activity of Cullin-RING E3 ubiquitin ligases by removing Nedd8 modifications from their Cullin subunits. Neddylation renders these complexes catalytically active, but deneddylation is also necessary for them to exchange adaptor subunits and avoid auto-ubiquitination. Although deneddylation is thought to be the primary function of the COP9 signalosome, additional activities have been ascribed to some of its subunits. We recently showed that COP9 subunits protect the transcriptional repressor and tumor suppressor Capicua from two distinct modes of degradation. Deneddylation by the COP9 signalosome inactivates a Cullin 1 complex that ubiquitinates Capicua following its phosphorylation by MAP kinase in response to Epidermal Growth Factor Receptor signaling. The CSN1b subunit also stabilizes unphosphorylated Capicua to control its basal level, independently of the deneddylase function of the complex. Here we further examine the importance of deneddylation for COP9 functions

Indexed as

AnimalsCells, CulturedCOP9 Signalosome ComplexCullin ProteinsDrosophila melanogasterDrosophila ProteinsMultiprotein ComplexesNEDD8 ProteinProteolysisUbiquitinationUbiquitin-Protein LigasesCOP9 Signalosome ComplexCullin ProteinsDrosophila ProteinsMultiprotein ComplexesNEDD8 ProteinNedd8 protein, DrosophilaUbiquitin-Protein LigasesCOP9 signalosomeCullinNedd8ubiquitin ligasewing disc

Identifiers

PMID29355077
PMCPMC6150624
OpenAlexW2789666259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.