Evidence map›Paper›PMID 29354781›Full record

ArticleJACC. Basic to translational science2017

Suppression of Arrhythmia by Enhancing Mitochondrial Ca

Maria K Schweitzer, Fabiola Wilting, Simon Sedej, Lisa Dreizehnter, Nathan J Dupper, Qinghai Tian, Alessandra Moretti, Ilaria My, Ohyun Kwon, Silvia G Priori and 7 more

Open access · goldAbstract read
In one paragraph

Article in JACC. Basic to translational science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 54 citations in OpenAlex.

  1. Zebrafish in Cardiovascular Disease Research: from Model to Application.International journal of biological sciences · 2026
    Review
  2. Increased Intermembrane Space [CaCirculation research · 2025
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Stem cell models of inherited arrhythmias.Nature cardiovascular research · 2024
    Review
  11. Article
  12. Distinct Effects of Mitochondrial NaJournal of the American Heart Association · 2023
    Article
  13. Cardioprotective Properties of Kaempferol: A Review.Plants (Basel, Switzerland) · 2023
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 4 countries.

Maria K SchweitzerWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.
Fabiola WiltingWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.
Simon SedejDepartment of Cardiology, Medical University of Graz, Graz, Austria.
Lisa DreizehnterI. Department of Medicine (Cardiology), Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Nathan J DupperDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, USA.
Qinghai TianInstitute for Molecular Cell Biology, University Medical Center, Saarland University, Homburg/Saar, Germany.
Alessandra MorettiI. Department of Medicine (Cardiology), Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Ilaria MyI. Department of Medicine (Cardiology), Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Ohyun KwonDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, USA.
Silvia G PrioriMolecular Cardiology, IRCCS Salvatore Maugeri Foundation, Pavia, Italy; Department of Molecular Medicine, University of Pavia, Italy.
Karl-Ludwig LaugwitzI. Department of Medicine (Cardiology), Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Ursula StorchWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.
Peter LippInstitute for Molecular Cell Biology, University Medical Center, Saarland University, Homburg/Saar, Germany.
Andreas BreitWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.
Michael Mederos Y SchnitzlerWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.
Thomas GudermannWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.
Johann SchredelsekerWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.
Ludwig-Maximilians-Universität München · DETechnical University of Munich · DESaarland University · DEUniversity of California, Los Angeles · USGerman Centre for Cardiovascular Research · DEIstituti di Ricovero e Cura a Carattere Scientifico · ITKlinikum rechts der Isar · DEMedical University of Graz · AT

Funding

Phosphine-Catalyzed Annulations and Their ApplicationsR01GM071779 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OHYUN KWON · 2006 to 2026
$5.7M
Austrian Science Fund FWF P 27637NIGMS NIH HHS R01 GM071779
6 · The paper itself

Abstract

Cardiovascular disease-related deaths frequently arise from arrhythmias, but treatment options are limited due to perilous side effects of commonly used antiarrhythmic drugs. Cardiac rhythmicity strongly depends on cardiomyocyte Ca

Indexed as

CPVTMCUMiCUpmitochondriaRyR2VDAC2

Identifiers

PMID29354781
PMCPMC5774336
OpenAlexW2767914877

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.